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- PSME3 abstract "Proteasome activator complex subunit 3 is a protein that in humans is encoded by the PSME3 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.".
- PSME3 entrezgene "10197".
- PSME3 wikiPageID "14753951".
- PSME3 wikiPageRevisionID "592872448".
- PSME3 hasPhotoCollection PSME3.
- PSME3 requireManualInspection "no".
- PSME3 summaryText "The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.".
- PSME3 updateCitations "yes".
- PSME3 updatePage "yes".
- PSME3 updateProteinBox "yes".
- PSME3 updateSummary "yes".
- PSME3 type Biomolecule.
- PSME3 type Protein.
- PSME3 type BiologicalObject.
- PSME3 comment "Proteasome activator complex subunit 3 is a protein that in humans is encoded by the PSME3 gene.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.".
- PSME3 label "PSME3".
- PSME3 label "PSME3".
- PSME3 sameAs PSME3.
- PSME3 sameAs m.03gwpyj.
- PSME3 sameAs Q7120729.
- PSME3 sameAs Q7120729.
- PSME3 wasDerivedFrom PSME3?oldid=592872448.
- PSME3 isPrimaryTopicOf PSME3.