Matches in DBpedia 2014 for { <http://dbpedia.org/resource/PTPN2> ?p ?o. }
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- PTPN2 abstract "Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.".
- PTPN2 entrezgene "5771".
- PTPN2 wikiPageID "14755169".
- PTPN2 wikiPageRevisionID "592875351".
- PTPN2 hasPhotoCollection PTPN2.
- PTPN2 requireManualInspection "no".
- PTPN2 summaryText "The protein encoded by this gene is a member of the protein tyrosine phosphatase family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.".
- PTPN2 updateCitations "yes".
- PTPN2 updatePage "yes".
- PTPN2 updateProteinBox "yes".
- PTPN2 updateSummary "yes".
- PTPN2 type Biomolecule.
- PTPN2 type Protein.
- PTPN2 type BiologicalObject.
- PTPN2 comment "Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.".
- PTPN2 label "PTPN2".
- PTPN2 sameAs m.03gwskl.
- PTPN2 sameAs Q7121002.
- PTPN2 sameAs Q7121002.
- PTPN2 wasDerivedFrom PTPN2?oldid=592875351.
- PTPN2 isPrimaryTopicOf PTPN2.