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- PVRL1 abstract "Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1, is a human gene that encodes a protein of immunoglobulin superfamily (IgSF) also considered a member of the nectins. It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).PVRL1 is adhesion molecule found in a wide range of tissues where is localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons. The cytoplasmic tail of PVRL1 can bind the protein afadin which is a scaffolding protein that binds actin.In the chemical synapse PVRL1 interacts with PVRL3 (nectin-3) and both proteins can be found in neuronal tissue already in early stages of brain developmen as well as in aging brains. Inerestingly the two proteins have been found to localize asymmetrically along the chemical synapse, with PVRL1 primarily on the axonal side and PVRL3 on the dendritic side.The protein has been revealed as one of the key playerse in mediating cellular entry of the Herpes simplex virus by interacting with the viral glycoprotein D (gD).".
- PVRL1 entrezgene "5818".
- PVRL1 wikiPageID "14756588".
- PVRL1 wikiPageRevisionID "592881099".
- PVRL1 hasPhotoCollection PVRL1.
- PVRL1 requireManualInspection "no".
- PVRL1 updateCitations "yes".
- PVRL1 updatePage "yes".
- PVRL1 updateProteinBox "yes".
- PVRL1 updateSummary "yes".
- PVRL1 subject Category:Clusters_of_differentiation.
- PVRL1 type Biomolecule.
- PVRL1 type Protein.
- PVRL1 type BiologicalObject.
- PVRL1 comment "Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1, is a human gene that encodes a protein of immunoglobulin superfamily (IgSF) also considered a member of the nectins. It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail.".
- PVRL1 label "PVRL1".
- PVRL1 sameAs m.03gww1g.
- PVRL1 sameAs Q7121133.
- PVRL1 sameAs Q7121133.
- PVRL1 sameAs PVRL1.
- PVRL1 wasDerivedFrom PVRL1?oldid=592881099.
- PVRL1 isPrimaryTopicOf PVRL1.