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• Pediatric_Trials_Network abstract "The Pediatric Trials Network (PTN) is a consortium of clinical research sites located around the United States that are cooperating in the design and conduct of clinical trials to improve health care for young patients. The network is sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).The work of the PTN addresses a critical lack of information regarding the impact of therapeutic agents on infants and children. Developing organs and changes in metabolism throughout infancy and childhood affect how drugs are processed by immature or maturing bodies; thus, age-dependent adjustments in doses are required to ensure that such therapies are used safely and effectively. Unfortunately, only a small percentage of drugs and devices approved by the Food and Drug Administration (FDA) have actually been studied in children and are labeled for pediatric use. Pediatricians, consequently, are often forced to prescribe medical therapies "off-label," or according to their best guess based on adult studies.To fill this knowledge gap, the PTN is studying the formulation, dosing, efficacy, and safety of drugs, as well as the development of medical devices, used in pediatric patients. In keeping with the goals of the Best Pharmaceuticals for Children Act (BPCA), data collected from PTN trials are helping regulators to revise FDA labels for safer and more effective use in infants and children.A map of sites currently participating in PTN trials may be viewed on the network's website [1].".
• Pediatric_Trials_Network wikiPageExternalLink NCT01506544?term=hydroxyurea&rank=5.
• Pediatric_Trials_Network wikiPageExternalLink NCT00942084?term=An+Open+Label+Study+to+Describe+the+Pharmacokinetics+of+Acyclovir+in+Premature+Infants&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink NCT01222585?term=Safety+and+Pharmacokinetics+of+Multiple+Dose+Metronidazole+in+Premature+Infants&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink NCT01431326?term=pops&rank=3.
• Pediatric_Trials_Network wikiPageExternalLink NCT01491919?term=lisinopril&rank=9.
• Pediatric_Trials_Network wikiPageExternalLink smhs.gwu.edu.
• Pediatric_Trials_Network wikiPageExternalLink unc.edu.
• Pediatric_Trials_Network wikiPageExternalLink www.childrensmercy.org.
• Pediatric_Trials_Network wikiPageExternalLink www.chop.edu.
• Pediatric_Trials_Network wikiPageExternalLink NCT01507090?term=TAPE&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink NCT01670136?term=NCT01670136&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink NCT01728363?term=Pharmacokinetics+of+antistaphylococcal+antibiotics+in+infants&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink NCT01744730?term=Safety+and+pharmacokinetics+of+multiple-dose+intravenous+and+oral+clindamycin+in+obese+children&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink NCT01945736?term=Pharmacokinetics+of+multiple-dose+methadone+in+children&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink NCT01994993?term=scamp&rank=1.
• Pediatric_Trials_Network wikiPageExternalLink www.dukehealth.org.
• Pediatric_Trials_Network wikiPageExternalLink 21980319.
• Pediatric_Trials_Network wikiPageExternalLink 22955430.
• Pediatric_Trials_Network wikiPageExternalLink 23602655.
• Pediatric_Trials_Network wikiPageExternalLink 23838776.
• Pediatric_Trials_Network wikiPageExternalLink pubmed?term=Determining+Population+and+Developmental+Pharmacokinetics+of+Metronidazole+Using+Plasma+and+Dried+Blood+Spot+Samples+from+Premature+Infants.&TransSchema=title&cmd=detailssearch.
• Pediatric_Trials_Network wikiPageExternalLink pubmed?term=PMC3173561.
• Pediatric_Trials_Network wikiPageExternalLink pubmed?term=Population+Pharmacokinetics+of+Intravenous+Acyclovir+in+Preterm+and+Term+Infants.+&TransSchema=title&cmd=detailssearch.
• Pediatric_Trials_Network wikiPageExternalLink index.aspx.
• Pediatric_Trials_Network wikiPageExternalLink college.
• Pediatric_Trials_Network wikiPageExternalLink www.ucsd.edu.
• Pediatric_Trials_Network wikiPageExternalLink www.vtc.vt.edu.
• Pediatric_Trials_Network wikiPageExternalLink www.wakehealth.edu.
• Pediatric_Trials_Network wikiPageExternalLink dcri.org.
• Pediatric_Trials_Network wikiPageExternalLink clinical-sites-interactive-map.
• Pediatric_Trials_Network wikiPageExternalLink copy_of_studying-obesity-and-drug-dosing-in-children.
• Pediatric_Trials_Network wikiPageExternalLink midazolam.
• Pediatric_Trials_Network wikiPageExternalLink safety-of-drugs-used-in-hospitalized-infants.
• Pediatric_Trials_Network wikiPageExternalLink safety-of-fluconazole-prophylaxis-in-infants.
• Pediatric_Trials_Network wikiPageExternalLink hydroxyurea-in-pediatric-patients-with-sickle-cell-anemia.
• Pediatric_Trials_Network wikiPageExternalLink pharmacokinetics-of-multiple-dose-methadone-in-children.
• Pediatric_Trials_Network wikiPageExternalLink pharmacokinetics-of-understudied-drugs-administered-to-children-per-standard-of-care.
• Pediatric_Trials_Network wikiPageExternalLink safety-and-pharmacokinetics-of-multiple-dose-intravenous-and-oral-clindamycin-in-obese-children.
• Pediatric_Trials_Network wikiPageExternalLink safety-and-pharmacokinetics-of-multiple-dose-lisinopril-in-pediatric-kidney-transplant-recipients.
• Pediatric_Trials_Network wikiPageExternalLink the-effect-of-obesity-on-the-pharmacokinetics-of-pantoprazole-in-children-and-adolescents.
• Pediatric_Trials_Network wikiPageExternalLink validation-of-the-mercy-tape.
• Pediatric_Trials_Network wikiPageExternalLink Pharmacokinetics-of-antistaphylococcal-antibiotics-in-infants.
• Pediatric_Trials_Network wikiPageExternalLink an-open-label-study-to-describe-the-pharmacokinetics-of-acyclovir-in-premature-infants.
• Pediatric_Trials_Network wikiPageExternalLink antibiotic-safety-in-infants-with-complicated-intra-abdominal-infections-scamp-trial.
• Pediatric_Trials_Network wikiPageExternalLink document.2013-09-16.1065972269.
• Pediatric_Trials_Network wikiPageExternalLink efficacy-of-antiviral-suppression-therapy-after-neonatal-hsv-infection-of-the-central-nervous-system.
• Pediatric_Trials_Network wikiPageExternalLink safety-and-pharmacokinetics-of-multiple-dose-metronidazole-in-premature-infants.
• Pediatric_Trials_Network wikiPageExternalLink the-ampicillin-in-infants-study.
• Pediatric_Trials_Network wikiPageExternalLink the-sildenafil-in-premature-neonates-trial.
• Pediatric_Trials_Network wikiPageExternalLink emmesweb.
• Pediatric_Trials_Network wikiPageExternalLink www.pediatrictrials.org.
• Pediatric_Trials_Network wikiPageID "41111636".
• Pediatric_Trials_Network wikiPageRevisionID "599610211".
• Pediatric_Trials_Network subject Category:Pediatrics_in_the_United_States.
• Pediatric_Trials_Network comment "The Pediatric Trials Network (PTN) is a consortium of clinical research sites located around the United States that are cooperating in the design and conduct of clinical trials to improve health care for young patients. The network is sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).The work of the PTN addresses a critical lack of information regarding the impact of therapeutic agents on infants and children.".
• Pediatric_Trials_Network label "Pediatric Trials Network".
• Pediatric_Trials_Network sameAs m.0zbxg16.
• Pediatric_Trials_Network sameAs Q17162656.
• Pediatric_Trials_Network sameAs Q17162656.
• Pediatric_Trials_Network wasDerivedFrom Pediatric_Trials_Network?oldid=599610211.
• Pediatric_Trials_Network isPrimaryTopicOf Pediatric_Trials_Network.