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- Pepducin abstract "Pepducins are novel cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G proteins. Pepducins were first developed at the Tufts Medical Center laboratories of Dr. Athan Kuliopulos and Dr. Lidija Covic.Pepducins utilize lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell-signaling pathways. A Pepducin molecule comprises a short peptide derived from a GPCR intracellular loop tethered to a hydrophobic moiety. This structure allows Pepducin lipopeptides to anchor in the cell membrane lipid bilayer and target the GPCR/G protein interface via a unique intracellular allosteric mechanism. Pepducins for over 15 different GPCRs have been successfully produced, several of which have shown activity in preclinical in vivo models.An anti-PAR4 pepducin extended bleeding time in mice and protected against systemic platelet activation and thrombosis.A CXCR4 agonist pepducin mobilizes bone marrow hematopoietic cells.As of 2011 none have entered clinical trials, although progress continues to be made.".
- Pepducin wikiPageID "19923477".
- Pepducin wikiPageRevisionID "594843464".
- Pepducin hasPhotoCollection Pepducin.
- Pepducin subject Category:Lipopeptides.
- Pepducin type Abstraction100002137.
- Pepducin type Amide114724264.
- Pepducin type Chemical114806838.
- Pepducin type Compound114818238.
- Pepducin type Material114580897.
- Pepducin type Matter100020827.
- Pepducin type OrganicCompound114727670.
- Pepducin type Part113809207.
- Pepducin type Peptide114743046.
- Pepducin type Peptides.
- Pepducin type PhysicalEntity100001930.
- Pepducin type Relation100031921.
- Pepducin type Substance100019613.
- Pepducin comment "Pepducins are novel cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G proteins. Pepducins were first developed at the Tufts Medical Center laboratories of Dr. Athan Kuliopulos and Dr. Lidija Covic.Pepducins utilize lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell-signaling pathways.".
- Pepducin label "Pepducin".
- Pepducin sameAs m.04q2w3x.
- Pepducin sameAs Q17143135.
- Pepducin sameAs Q17143135.
- Pepducin sameAs Pepducin.
- Pepducin wasDerivedFrom Pepducin?oldid=594843464.
- Pepducin isPrimaryTopicOf Pepducin.