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- Peptide_T abstract "Peptide T is an HIV entry inhibitor discovered in 1986 by National Institutes of Health (NIH) researchers. Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells.Peptide T has several positive effects related to HIV disease and Neuro-AIDS. A placebo-controlled, three site, 200+ patient NIH-funded clinical trial, which focused on neurocognitive improvements, was conducted between 1990 and 1995. The results showed that peptide T was not significantly different from placebo on the study primary end points. However, peptide T was associated with improved performance in the subgroup of patients with more severe cognitive impairment.A long-delayed analysis of antiviral effects from the 1996 NIH study showed peripheral viral load (combined plasma and serum) was significantly reduced in the DAPTA-treated group. An eleven person study for peptide T effects on cellular viral load showed reductions in the persistently infected monocyte reservoir to undetectable levels in most of the patients. Elimination of viral reservoirs, such as the monocytes, is an important treatment goal. DAPTA has been shown to substantially suppress brain inflammation and block proinflammatory cytokine signaling pathways in a small animal model of Alzheimer's disease.".
- Peptide_T iupacName "(L)-Alanyl-(L)-seryl-(L)-threonyl-(L)-threonyl-(L)-threonyl-(L)-asparaginyl-(L)-tyrosyl-(L)-threonine".
- Peptide_T thumbnail Peptide_T.svg?width=300.
- Peptide_T wikiPageID "20097680".
- Peptide_T wikiPageRevisionID "601261350".
- Peptide_T hasPhotoCollection Peptide_T.
- Peptide_T imagefile "Peptide T.svg".
- Peptide_T imagesize "250".
- Peptide_T iupacname "(L)-Alanyl-(L)-seryl-(L)-threonyl-(L)-threonyl-(L)-threonyl-(L)-asparaginyl-(L)-tyrosyl-(L)-threonine".
- Peptide_T subject Category:Entry_inhibitors.
- Peptide_T subject Category:Peptides.
- Peptide_T type Abstraction100002137.
- Peptide_T type Amide114724264.
- Peptide_T type Chemical114806838.
- Peptide_T type Compound114818238.
- Peptide_T type Material114580897.
- Peptide_T type Matter100020827.
- Peptide_T type OrganicCompound114727670.
- Peptide_T type Part113809207.
- Peptide_T type Peptide114743046.
- Peptide_T type Peptides.
- Peptide_T type PhysicalEntity100001930.
- Peptide_T type Relation100031921.
- Peptide_T type Substance100019613.
- Peptide_T type ChemicalCompound.
- Peptide_T type ChemicalSubstance.
- Peptide_T type ChemicalObject.
- Peptide_T type Thing.
- Peptide_T comment "Peptide T is an HIV entry inhibitor discovered in 1986 by National Institutes of Health (NIH) researchers. Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells.Peptide T has several positive effects related to HIV disease and Neuro-AIDS.".
- Peptide_T label "Peptide T".
- Peptide_T sameAs m.04yf0hp.
- Peptide_T sameAs Q7166522.
- Peptide_T sameAs Q7166522.
- Peptide_T sameAs Peptide_T.
- Peptide_T wasDerivedFrom Peptide_T?oldid=601261350.
- Peptide_T depiction Peptide_T.svg.
- Peptide_T isPrimaryTopicOf Peptide_T.
