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• Pernicious_anemia abstract "Pernicious anemia (also known as Biermer's anemia, Addison's anemia, or Addison–Biermer anemia) is one of many types of the larger family of megaloblastic anemias. One way pernicious anemia can develop is by loss of gastric parietal cells, which are responsible, in part, for the secretion of intrinsic factor, a protein essential for subsequent absorption of vitamin B12 in the ileum.Usually seated in an atrophic gastritis, the autoimmune destruction of gastric parietal cells (and autoantibody inactivation of intrinsic factor) leads to a lack of intrinsic factor. Since the absorption from the gut of normal dietary amounts of vitamin B12 is dependent on intrinsic factor, the loss of intrinsic factor leads to vitamin B12 deficiency. While the term 'pernicious anemia' is sometimes also incorrectly used to indicate megaloblastic anemia due to any cause of B12 deficiency, its proper usage refers to that caused by atrophic gastritis, parietal cell loss, and lack of intrinsic factor only.The loss of ability to absorb vitamin B12 (B12) is the most common cause of adult B12 deficiency. Impaired absorption of vitamin B12 may be due to a loss of intrinsic factor or to a number of other conditions that decrease production of gastric acid, which also plays a part in the absorption of B12 from foods.Historically, pernicious anemia (PA) was detected only after it became "clinical" (caused an overt disease state) and the anemia was well established, i.e., liver stores of B12 had been depleted. The "pernicious" aspect of the disease – prior to the discovery of treatment – was its invariably fatal prognosis, similar to leukemia at that time. However, in the time since elucidation of the cause of the disease, modern tests that specifically target B12 absorption can be used to diagnose the disease before it becomes clinically apparent. In such cases, the disease may be diagnosed and treated without the patient ever becoming ill.Replacement of vitamin stores does not correct the defect in absorption from loss of intrinsic factor. Since the defect defines the disease, people without the ability to absorb B12 in this way will have pernicious anemia for the remainder of their lives. However, unless the patient has sustained permanent peripheral nerve damage before treatment, regular B12 replacement will keep PA in check, with no anemia and no further symptoms.Although initial treatment of the disease usually involves injections of B12 to rapidly replace body stores, a number of studies have shown long-term vitamin replacement treatment may be maintained with high-dose oral B12 supplements, since sufficient B12 is absorbed from these by a normal intestine, even without any intrinsic factor. In this regard, nasal and sublingual forms of B12 have not been found to have any special value over simple swallowed tablets.".
• Pernicious_anemia diseasesdb "9870".
• Pernicious_anemia emedicineSubject "med".
• Pernicious_anemia emedicineTopic "1799".
• Pernicious_anemia icd10 "D51.0".
• Pernicious_anemia icd9 "281.0".
• Pernicious_anemia medlineplus "000569".
• Pernicious_anemia meshId "D000752".
• Pernicious_anemia thumbnail RBC_micrograph.jpg?width=300.
• Pernicious_anemia wikiPageExternalLink gpc.php.
• Pernicious_anemia wikiPageExternalLink GPC.htm.
• Pernicious_anemia wikiPageExternalLink 000569.htm.
• Pernicious_anemia wikiPageExternalLink www.pernicious-anaemia-society.org.
• Pernicious_anemia wikiPageExternalLink www.rareanemias.webs.com.
• Pernicious_anemia wikiPageID "538993".
• Pernicious_anemia wikiPageRevisionID "606124435".
• Pernicious_anemia diseasesdb "9870".
• Pernicious_anemia emedicinesubj "med".
• Pernicious_anemia emedicinetopic "1799".
• Pernicious_anemia hasPhotoCollection Pernicious_anemia.
• Pernicious_anemia icd "281".
• Pernicious_anemia icd "D51.0".
• Pernicious_anemia medlineplus "569".
• Pernicious_anemia meshid "D000752".
• Pernicious_anemia name "Pernicious anemia".
• Pernicious_anemia wordnet_type synset-disease-noun-1.
• Pernicious_anemia subject Category:Hematopathology.
• Pernicious_anemia subject Category:Nutritional_anemias.
• Pernicious_anemia type Disease.
• Pernicious_anemia type AilmentCondition.
• Pernicious_anemia type Situation.
• Pernicious_anemia comment "Pernicious anemia (also known as Biermer's anemia, Addison's anemia, or Addison–Biermer anemia) is one of many types of the larger family of megaloblastic anemias.".
• Pernicious_anemia label "Anemia perniciosa".
• Pernicious_anemia label "Anemia perniciosa".
• Pernicious_anemia label "Anemia perniciosa".
• Pernicious_anemia label "Anémie pernicieuse".
• Pernicious_anemia label "Niedokrwistość Addisona-Biermera".
• Pernicious_anemia label "Pernicieuze anemie".
• Pernicious_anemia label "Pernicious anemia".
• Pernicious_anemia label "Perniziöse Anämie".
• Pernicious_anemia label "悪性貧血".
• Pernicious_anemia sameAs Perniziöse_Anämie.
• Pernicious_anemia sameAs Anemia_perniciosa.
• Pernicious_anemia sameAs Anemia_kaltegarri.
• Pernicious_anemia sameAs Anémie_pernicieuse.
• Pernicious_anemia sameAs Anemia_perniciosa.
• Pernicious_anemia sameAs 悪性貧血.
• Pernicious_anemia sameAs Pernicieuze_anemie.
• Pernicious_anemia sameAs Niedokrwistość_Addisona-Biermera.
• Pernicious_anemia sameAs Anemia_perniciosa.
• Pernicious_anemia sameAs m.02mzv1.
• Pernicious_anemia sameAs Q1346016.
• Pernicious_anemia sameAs Q1346016.
• Pernicious_anemia sameAs C0002892.
• Pernicious_anemia wasDerivedFrom Pernicious_anemia?oldid=606124435.
• Pernicious_anemia depiction RBC_micrograph.jpg.
• Pernicious_anemia isPrimaryTopicOf Pernicious_anemia.
• Pernicious_anemia name "Pernicious anemia".