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- Phase_variation abstract "Phase variation is a method for dealing with rapidly varying environments without requiring random mutation employed by various types of bacteria, including Salmonella species. It involves the variation of protein expression, frequently in an on-off fashion, within different parts of a bacterial population. Although it has been most commonly studied in the context of immune evasion, it is observed in many other areas as well. Phase variation is defined as the random switching of phenotype at frequencies that are much higher (sometimes >1%) than classical mutation rates. Phase variation contributes to virulence by generating heterogeneity; certain environmental or host pressures select those bacteria that express the best adapted phenotypeSalmonella use this technique to switch between different types of the protein flagellin. As a result, flagella with different structures are assembled. Once an adaptive response has been mounted against one type of flagellin, or if a previous encounter has left the adaptive immune system ready to deal with one type of flagellin, switching types renders previously high affinity antibodies, TCRs and BCRs ineffective against the flagella.".
- Phase_variation thumbnail Phase_variation_site_specific_recombination_-_inversion.jpg?width=300.
- Phase_variation wikiPageID "15397737".
- Phase_variation wikiPageRevisionID "594984398".
- Phase_variation hasPhotoCollection Phase_variation.
- Phase_variation subject Category:Bacteria.
- Phase_variation type Bacteria.
- Phase_variation type Bacteria101348530.
- Phase_variation type LivingThing100004258.
- Phase_variation type Microorganism101326291.
- Phase_variation type Object100002684.
- Phase_variation type Organism100004475.
- Phase_variation type PhysicalEntity100001930.
- Phase_variation type Whole100003553.
- Phase_variation comment "Phase variation is a method for dealing with rapidly varying environments without requiring random mutation employed by various types of bacteria, including Salmonella species. It involves the variation of protein expression, frequently in an on-off fashion, within different parts of a bacterial population. Although it has been most commonly studied in the context of immune evasion, it is observed in many other areas as well.".
- Phase_variation label "Phase variation".
- Phase_variation label "相変異 (細菌)".
- Phase_variation sameAs 相変異_(細菌).
- Phase_variation sameAs m.03m71bn.
- Phase_variation sameAs Q7180971.
- Phase_variation sameAs Q7180971.
- Phase_variation sameAs Phase_variation.
- Phase_variation wasDerivedFrom Phase_variation?oldid=594984398.
- Phase_variation depiction Phase_variation_site_specific_recombination_-_inversion.jpg.
- Phase_variation isPrimaryTopicOf Phase_variation.
