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- Phosphatidylinositol_phosphate_kinases abstract "Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that are derivatives of phosphatidylinositol (PtdIns). It has been found that PtdIns is only phosphorylated on three (3,4,5) of its five hydroxyl groups, possibly because D-2 and D-6 hydroxyl groups cannot be phosphorylated because of steric hindrance. All 7 combinations of phosphorylated PtdIns have been found in animals, all except PtdIns(3,4,5)P3 have been found in plants.PIPKs are today divided into three groups, type I, II and III that share significant sequence homology but differ in the substrate specificities, subcellular localisations and functions.Type 1 are PIPKs that phosphorylate PtdIns4P to PtdIns(4,5)P2 and are called PtdIns4P 5-kinases because they phosphorylate on the D-5 hydroxyl group. Type II PIPKs phosphorylate PtdIns5P at the D-4 site and are called PtdIns5P 4-kinases. And finally PIPKs of type III are PtdIns3P 5-kinases that phosphorylate PtdIns to PtdIns(3,5)P2, which prototype is Fab1 in yeast (see [1] for descriptive picture). The substrate specificity of type I and II depends on the so-called activation loop. The activation loop is a segment of 22 to 27 amino acid residues, located close to the C-terminal end of the catalytic domain in all PIPKs. When the activation loops of a type I and a type II PIPK were swapped, the chimera with type I backbone showed specificity for type II substrate, and vice versa for the other chimera.".
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- Phosphatidylinositol_phosphate_kinases wikiPageID "9060393".
- Phosphatidylinositol_phosphate_kinases wikiPageRevisionID "537555509".
- Phosphatidylinositol_phosphate_kinases hasPhotoCollection Phosphatidylinositol_phosphate_kinases.
- Phosphatidylinositol_phosphate_kinases subject Category:Enzymes.
- Phosphatidylinositol_phosphate_kinases type Abstraction100002137.
- Phosphatidylinositol_phosphate_kinases type Activator114723079.
- Phosphatidylinositol_phosphate_kinases type Catalyst114723628.
- Phosphatidylinositol_phosphate_kinases type Chemical114806838.
- Phosphatidylinositol_phosphate_kinases type Compound114818238.
- Phosphatidylinositol_phosphate_kinases type Enzyme114732946.
- Phosphatidylinositol_phosphate_kinases type Enzymes.
- Phosphatidylinositol_phosphate_kinases type Macromolecule114944888.
- Phosphatidylinositol_phosphate_kinases type Material114580897.
- Phosphatidylinositol_phosphate_kinases type Matter100020827.
- Phosphatidylinositol_phosphate_kinases type Molecule114682133.
- Phosphatidylinositol_phosphate_kinases type OrganicCompound114727670.
- Phosphatidylinositol_phosphate_kinases type Part113809207.
- Phosphatidylinositol_phosphate_kinases type PhysicalEntity100001930.
- Phosphatidylinositol_phosphate_kinases type Protein114728724.
- Phosphatidylinositol_phosphate_kinases type Relation100031921.
- Phosphatidylinositol_phosphate_kinases type Substance100019613.
- Phosphatidylinositol_phosphate_kinases type Thing100002452.
- Phosphatidylinositol_phosphate_kinases type Unit109465459.
- Phosphatidylinositol_phosphate_kinases comment "Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that are derivatives of phosphatidylinositol (PtdIns). It has been found that PtdIns is only phosphorylated on three (3,4,5) of its five hydroxyl groups, possibly because D-2 and D-6 hydroxyl groups cannot be phosphorylated because of steric hindrance.".
- Phosphatidylinositol_phosphate_kinases label "Phosphatidylinositol phosphate kinases".
- Phosphatidylinositol_phosphate_kinases sameAs m.027w6qf.
- Phosphatidylinositol_phosphate_kinases sameAs Q7187464.
- Phosphatidylinositol_phosphate_kinases sameAs Q7187464.
- Phosphatidylinositol_phosphate_kinases sameAs Phosphatidylinositol_phosphate_kinases.
- Phosphatidylinositol_phosphate_kinases wasDerivedFrom Phosphatidylinositol_phosphate_kinases?oldid=537555509.
- Phosphatidylinositol_phosphate_kinases isPrimaryTopicOf Phosphatidylinositol_phosphate_kinases.
