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- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase abstract "In molecular biology, the protein domain SAICAR synthase is an enzyme which catalyses a reaction to create SAICAR. In enzymology, this enzyme is also known as phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6). It is an enzyme that catalyzes the chemical reactionATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido]succinateThe 3 substrates of this enzyme are ATP, 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, and L-aspartate, whereas its 4 products are ADP, phosphate, [[(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-]], and [[carboxamido]succinate]].This enzyme belongs to the family of ligases, to be specific those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming). This enzyme participates in purine metabolism.This particular protein family is of huge importance as it is found in all three domains of life. It is the seventh step in the pathway of purine biosynthesis. Purines are vital to all cells are they are involved in energy metabolism and DNA synthesis. Furthermore, they are of specific interest to scientific researchers as the study of the purine biosynthesis pathway could lead to the development of chemotherapeutic drugs. This is because most cancers lack a salvage pathway for adenine nucleotides and rely entirely on the SAICAR pathway.".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase ecNumber "6.3.2.6".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase thumbnail PDB_1kut_EBI.jpg?width=300.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase wikiPageID "14286218".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase wikiPageRevisionID "589809348".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase caption "Structural genomics, protein TM1243,".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase casNumber "9023".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase ecNumber "6.3".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase goCode "4639".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase hasPhotoCollection Phosphoribosylaminoimidazolesuccinocarboxamide_synthase.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase interpro "IPR001636".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase iubmbEcNumber "6".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase name "SAICAR synthase".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase name "SAICAR synthetase".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase pfam "PF01259".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase prosite "PDOC00810".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase scop "1".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase symbol "SAICAR_synt".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase subject Category:EC_6.3.2.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase subject Category:Enzymes_of_known_structure.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase subject Category:Protein_domains.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Abstraction100002137.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Activator114723079.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Catalyst114723628.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Chemical114806838.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Compound114818238.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Enzyme114732946.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type EnzymesOfKnownStructure.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Macromolecule114944888.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Material114580897.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Matter100020827.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Molecule114682133.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type OrganicCompound114727670.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Part113809207.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type PhysicalEntity100001930.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Protein114728724.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Relation100031921.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Substance100019613.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Thing100002452.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Unit109465459.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Biomolecule.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type Enzyme.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase type BiologicalObject.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase comment "In molecular biology, the protein domain SAICAR synthase is an enzyme which catalyses a reaction to create SAICAR. In enzymology, this enzyme is also known as phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6).".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase label "Phosphoribosylaminoimidazolesuccinocarboxamide synthase".
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase sameAs m.03c_csj.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase sameAs Q7187551.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase sameAs Q7187551.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase sameAs Phosphoribosylaminoimidazolesuccinocarboxamide_synthase.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase wasDerivedFrom Phosphoribosylaminoimidazolesuccinocarboxamide_synthase?oldid=589809348.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase depiction PDB_1kut_EBI.jpg.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase isPrimaryTopicOf Phosphoribosylaminoimidazolesuccinocarboxamide_synthase.
- Phosphoribosylaminoimidazolesuccinocarboxamide_synthase name "SAICAR synthase".
