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- Piquindone abstract "Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. It acts as a selective D2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial. Unlike most other D2 receptor ligands, piquindone displays Na2+-dependent binding, a property it shares with tropapride, zetidoline, and metoclopramide.In clinical trials piquindone was found to possess moderate efficacy in treating positive symptoms of schizophrenia, and notably, was also modestly effective for negative symptoms, though this was just under statistical significance. Additionally, relative to haloperidol, it was found to possesses significantly fewer extrapyramidal symptoms and had a much lower propensity for inducing tardive dyskinesia, indicating its atypical nature. In addition to psychosis, piquindone has also been found to be effective in the treatment of Tourette's syndrome in numerous clinical studies.".
- Piquindone atcPrefix "none".
- Piquindone casNumber "78541-97-6".
- Piquindone casSupplemental "83784-19-4 (hydrochloride)".
- Piquindone fdaUniiCode "O1C9WXY65C".
- Piquindone iupacName "(4aS,8aS)-3-ethyl-2,6-dimethyl-1,4a,5,6,7,8,8a,9-octahydro-4H-pyrrolo[2,3-g]isoquinolin-4-one".
- Piquindone pubchem "121903".
- Piquindone thumbnail Piquindone.png?width=300.
- Piquindone wikiPageID "26907451".
- Piquindone wikiPageRevisionID "604170495".
- Piquindone atcPrefix "none".
- Piquindone c "15".
- Piquindone casNumber "78541".
- Piquindone casSupplemental "83784".
- Piquindone chembl "1192678".
- Piquindone chemspiderid "108751".
- Piquindone h "22".
- Piquindone hasPhotoCollection Piquindone.
- Piquindone iupacName "-3".
- Piquindone legalStatus "Uncontrolled".
- Piquindone molecularWeight "246.35".
- Piquindone n "2".
- Piquindone o "1".
- Piquindone pubchem "121903".
- Piquindone routesOfAdministration "Oral".
- Piquindone smiles "O=C2c1cC[C@H]3[C@H]2CNC".
- Piquindone unii "O1C9WXY65C".
- Piquindone subject Category:Atypical_antipsychotics.
- Piquindone subject Category:Pyrroloisoquinolines.
- Piquindone type Agent114778436.
- Piquindone type AtypicalAntipsychotics.
- Piquindone type CausalAgent100007347.
- Piquindone type Drug103247620.
- Piquindone type DrugOfAbuse103248958.
- Piquindone type MajorTranquilizer103713736.
- Piquindone type Matter100020827.
- Piquindone type Medicine103740161.
- Piquindone type PhysicalEntity100001930.
- Piquindone type PsychotropicAgent104017429.
- Piquindone type Sedative-hypnotic104166841.
- Piquindone type Sedative104166553.
- Piquindone type Substance100020090.
- Piquindone type Tranquilizer104470232.
- Piquindone type Drug.
- Piquindone type FunctionalSubstance.
- Piquindone comment "Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. It acts as a selective D2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial.".
- Piquindone label "Piquindone".
- Piquindone sameAs m.0bmgntz.
- Piquindone sameAs Q7197544.
- Piquindone sameAs Q7197544.
- Piquindone sameAs Piquindone.
- Piquindone wasDerivedFrom Piquindone?oldid=604170495.
- Piquindone depiction Piquindone.png.
- Piquindone isPrimaryTopicOf Piquindone.
