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- Pivaloyloxymethyl abstract "Pivaloyloxymethyl (POM, pivoxil, pivoxyl) is a protecting group used in organic synthesis. The POM radical has the formula (CH3)3C-CO-O-CH2. The POM group is also sometimes used to produce prodrugs. For example, the POM group can be attached to a negatively charged organophosphate group(s) of a drug causing a neutralization of the negative charge, which can allow the drug to become more lipid soluble and thus more able to diffuse passively across cell membranes into cells. Upon entry into cells, the POM portion of the molecule can be removed by cellular processes resulting in release of active drug. Clinically used prodrugs containing pivaloyloxymethyl groups include adefovir dipivoxil, pivampicillin, cefditoren pivoxil, pivmecillinam, and valproate pivoxil. Tenofovir disoproxil fumarate contains a very similar prodrug group.".
- Pivaloyloxymethyl thumbnail Pivaloyloxymethyl.svg?width=300.
- Pivaloyloxymethyl wikiPageID "14454590".
- Pivaloyloxymethyl wikiPageRevisionID "586090469".
- Pivaloyloxymethyl hasPhotoCollection Pivaloyloxymethyl.
- Pivaloyloxymethyl subject Category:Carboxylate_esters.
- Pivaloyloxymethyl subject Category:Protecting_groups.
- Pivaloyloxymethyl type Abstraction100002137.
- Pivaloyloxymethyl type CarboxylateEsters.
- Pivaloyloxymethyl type Chemical114806838.
- Pivaloyloxymethyl type Compound114818238.
- Pivaloyloxymethyl type Ester114850483.
- Pivaloyloxymethyl type Group100031264.
- Pivaloyloxymethyl type Material114580897.
- Pivaloyloxymethyl type Matter100020827.
- Pivaloyloxymethyl type OrganicCompound114727670.
- Pivaloyloxymethyl type Part113809207.
- Pivaloyloxymethyl type PhysicalEntity100001930.
- Pivaloyloxymethyl type ProtectingGroups.
- Pivaloyloxymethyl type Relation100031921.
- Pivaloyloxymethyl type Substance100019613.
- Pivaloyloxymethyl comment "Pivaloyloxymethyl (POM, pivoxil, pivoxyl) is a protecting group used in organic synthesis. The POM radical has the formula (CH3)3C-CO-O-CH2. The POM group is also sometimes used to produce prodrugs. For example, the POM group can be attached to a negatively charged organophosphate group(s) of a drug causing a neutralization of the negative charge, which can allow the drug to become more lipid soluble and thus more able to diffuse passively across cell membranes into cells.".
- Pivaloyloxymethyl label "Pivaloyloxymethyl".
- Pivaloyloxymethyl sameAs m.03d40ww.
- Pivaloyloxymethyl sameAs Q7199625.
- Pivaloyloxymethyl sameAs Q7199625.
- Pivaloyloxymethyl sameAs Pivaloyloxymethyl.
- Pivaloyloxymethyl wasDerivedFrom Pivaloyloxymethyl?oldid=586090469.
- Pivaloyloxymethyl depiction Pivaloyloxymethyl.svg.
- Pivaloyloxymethyl isPrimaryTopicOf Pivaloyloxymethyl.
