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- Plasmacytoid_dendritic_cell abstract "Plasmacytoid dendritic cells (pDCs) are innate immune cells that circulate in the blood and are found in peripheral lymphoid organs. They constitute < 0.4% of peripheral blood mononuclear cells (PBMC). In humans these cells express the surface markers CD123, BDCA-2(CD303) and BDCA-4(CD304), but do not express high levels of CD11c or CD14, which distinguishes them from conventional dendritic cells or monocytes, respectively. Mouse pDC express CD11c, B220, BST-2/Tetherin (mPDCA) and Siglec-H and are negative for CD11b. As components of the innate immune system, these cells express intracellular Toll-like receptors 7 and 9 which detect ssRNA and CpG DNA motifs, respectively. Upon stimulation and subsequent activation, these cells produce large amounts of type I interferon (mainly IFN-α (alpha) and IFN-β (beta)), which are critical pleiotropic anti-viral compounds mediating a wide range of effects. The number of circulating pDCs are found to be decreased during chronic HIV infection as well as HCV infection.".
- Plasmacytoid_dendritic_cell wikiPageID "5682997".
- Plasmacytoid_dendritic_cell wikiPageRevisionID "606552086".
- Plasmacytoid_dendritic_cell hasPhotoCollection Plasmacytoid_dendritic_cell.
- Plasmacytoid_dendritic_cell subject Category:Blood_cells.
- Plasmacytoid_dendritic_cell type BloodCell105449268.
- Plasmacytoid_dendritic_cell type BloodCells.
- Plasmacytoid_dendritic_cell type Cell100006484.
- Plasmacytoid_dendritic_cell type LivingThing100004258.
- Plasmacytoid_dendritic_cell type Object100002684.
- Plasmacytoid_dendritic_cell type PhysicalEntity100001930.
- Plasmacytoid_dendritic_cell type SomaticCell105430628.
- Plasmacytoid_dendritic_cell type Whole100003553.
- Plasmacytoid_dendritic_cell comment "Plasmacytoid dendritic cells (pDCs) are innate immune cells that circulate in the blood and are found in peripheral lymphoid organs. They constitute < 0.4% of peripheral blood mononuclear cells (PBMC). In humans these cells express the surface markers CD123, BDCA-2(CD303) and BDCA-4(CD304), but do not express high levels of CD11c or CD14, which distinguishes them from conventional dendritic cells or monocytes, respectively.".
- Plasmacytoid_dendritic_cell label "Plasmacytoid dendritic cell".
- Plasmacytoid_dendritic_cell sameAs Plazmacytoidní_dendritická_buňka.
- Plasmacytoid_dendritic_cell sameAs m.05pdb2v.
- Plasmacytoid_dendritic_cell sameAs Q12045567.
- Plasmacytoid_dendritic_cell sameAs Q12045567.
- Plasmacytoid_dendritic_cell sameAs Plasmacytoid_dendritic_cell.
- Plasmacytoid_dendritic_cell wasDerivedFrom Plasmacytoid_dendritic_cell?oldid=606552086.
- Plasmacytoid_dendritic_cell isPrimaryTopicOf Plasmacytoid_dendritic_cell.