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- Polynucleotide_phosphorylase abstract "Polynucleotide Phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. That is, it dismantles the RNA chain starting at the 3' end and working toward the 5' end. It also synthesizes long, highly heteropolymeric tails in vivo. It accounts for all of the observed residual polyadenylylation in strains of Escherichia coli missing the normal polyadenylylation enzyme.It is involved on mRNA processing and degradation in bacteria, plants, and in humans.In humans, the enzyme is encoded by the PNPT1 gene. In its active form, the protein forms a ring structure consisting of three PNPase molecules. Each PNPase molecule consists of two RNase PH domains, an S1 RNA binding domain and a K-homology domain. The protein is present in bacteria and in the chloroplasts and mitochondria of some eukaryotic cells. In eukaryotes and archaea, a structurally and evolutionary related complex exists, called the exosome.The same abbreviation (PNPase) is also used for another, otherwise unrelated enzyme, Purine nucleoside phosphorylase.".
- Polynucleotide_phosphorylase ecNumber "2.7.7.8".
- Polynucleotide_phosphorylase thumbnail Crystal_structure_1E3P.jpg?width=300.
- Polynucleotide_phosphorylase wikiPageID "11331492".
- Polynucleotide_phosphorylase wikiPageRevisionID "592827801".
- Polynucleotide_phosphorylase altsymbols "PNPase, OLD35, old-35".
- Polynucleotide_phosphorylase arm "p".
- Polynucleotide_phosphorylase band "15".
- Polynucleotide_phosphorylase caption "Structure of the PNPase trimer from Streptomyces antibioticus. PDB 1e3p.".
- Polynucleotide_phosphorylase casNumber "9014-12-04".
- Polynucleotide_phosphorylase chromosome "2".
- Polynucleotide_phosphorylase ecNumber "2.7".
- Polynucleotide_phosphorylase ecnumber "2.7".
- Polynucleotide_phosphorylase entrezgene "87178".
- Polynucleotide_phosphorylase goCode "4654".
- Polynucleotide_phosphorylase hasPhotoCollection Polynucleotide_phosphorylase.
- Polynucleotide_phosphorylase hgncid "23166".
- Polynucleotide_phosphorylase iubmbEcNumber "2".
- Polynucleotide_phosphorylase name "Human PNPase I".
- Polynucleotide_phosphorylase name "Polynucleotide Phosphorylase".
- Polynucleotide_phosphorylase omim "610316".
- Polynucleotide_phosphorylase pdb "1000".
- Polynucleotide_phosphorylase refseq "NM_033109".
- Polynucleotide_phosphorylase symbol "PNPASE".
- Polynucleotide_phosphorylase uniprot "Q8TCS8".
- Polynucleotide_phosphorylase width "220".
- Polynucleotide_phosphorylase subject Category:EC_2.7.7.
- Polynucleotide_phosphorylase subject Category:Genes_mutated_in_mice.
- Polynucleotide_phosphorylase subject Category:Ribonucleases.
- Polynucleotide_phosphorylase type Abstraction100002137.
- Polynucleotide_phosphorylase type Activator114723079.
- Polynucleotide_phosphorylase type Arrangement107938773.
- Polynucleotide_phosphorylase type Catalyst114723628.
- Polynucleotide_phosphorylase type Chemical114806838.
- Polynucleotide_phosphorylase type Compound114818238.
- Polynucleotide_phosphorylase type Enzyme114732946.
- Polynucleotide_phosphorylase type Gene105436752.
- Polynucleotide_phosphorylase type GenesMutatedInMice.
- Polynucleotide_phosphorylase type Group100031264.
- Polynucleotide_phosphorylase type Macromolecule114944888.
- Polynucleotide_phosphorylase type Material114580897.
- Polynucleotide_phosphorylase type Matter100020827.
- Polynucleotide_phosphorylase type Molecule114682133.
- Polynucleotide_phosphorylase type Ordering108456993.
- Polynucleotide_phosphorylase type OrganicCompound114727670.
- Polynucleotide_phosphorylase type Part113809207.
- Polynucleotide_phosphorylase type PhysicalEntity100001930.
- Polynucleotide_phosphorylase type Protein114728724.
- Polynucleotide_phosphorylase type Relation100031921.
- Polynucleotide_phosphorylase type Sequence108459252.
- Polynucleotide_phosphorylase type Series108457976.
- Polynucleotide_phosphorylase type Substance100019613.
- Polynucleotide_phosphorylase type Thing100002452.
- Polynucleotide_phosphorylase type Unit109465459.
- Polynucleotide_phosphorylase type Biomolecule.
- Polynucleotide_phosphorylase type Enzyme.
- Polynucleotide_phosphorylase type ProteinMolecule.
- Polynucleotide_phosphorylase type BiologicalObject.
- Polynucleotide_phosphorylase comment "Polynucleotide Phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. That is, it dismantles the RNA chain starting at the 3' end and working toward the 5' end. It also synthesizes long, highly heteropolymeric tails in vivo.".
- Polynucleotide_phosphorylase label "Polynucleotide phosphorylase".
- Polynucleotide_phosphorylase sameAs m.02r7_hr.
- Polynucleotide_phosphorylase sameAs Q7226662.
- Polynucleotide_phosphorylase sameAs Q7226662.
- Polynucleotide_phosphorylase sameAs Polynucleotide_phosphorylase.
- Polynucleotide_phosphorylase wasDerivedFrom Polynucleotide_phosphorylase?oldid=592827801.
- Polynucleotide_phosphorylase depiction Crystal_structure_1E3P.jpg.
- Polynucleotide_phosphorylase isPrimaryTopicOf Polynucleotide_phosphorylase.
- Polynucleotide_phosphorylase name "Polynucleotide Phosphorylase".
