Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Presenilin> ?p ?o. }
Showing items 1 to 100 of
100
with 100 items per page.
- Presenilin abstract "Presenilins are a family of related multi-pass transmembrane proteins that function as a part of the gamma-secretase intramembrane protease complex. They were first identified in screens for mutations causing early onset forms of familial Alzheimer's Disease by Peter St George-Hyslop at the Centre for Research in Neurodegenerative Diseases at the University of Toronto, and now also at the University of Cambridge. Vertebrates have two presenilin genes, called PSEN1 (located on chromosome 14 in humans) that encodes presenilin 1 (PS-1) and PSEN2 (on chromosome 1 in humans) that codes for presenilin 2 (PS-2). Both genes show conservation between species, with little difference between rat and human presenilins. The nematode worm C. elegans has two genes that resemble the presenilins and appear to be functionally similar, sel-12 and hop-1.Presenilins undergo cleavage in an alpha helical region of one of the cytoplasmic loops to produce a larger N-terminal and a smaller C-terminal fragment that together form part of the functional protein. Cleavage of presenilin 1 can be prevented by a mutation that causes the loss of exon 9, and results in loss of function. Presenilins play a key role in the modulation of intracellular Ca2+ involved in presynaptic neurotransmitter release and long-term potentiation induction.Dominant mutations in the genes that encode presenilin proteins are the most common cause of familial early-onset Alzheimer's disease.".
- Presenilin arm "q".
- Presenilin band "24.3".
- Presenilin band "31".
- Presenilin chromosome "1".
- Presenilin chromosome "14".
- Presenilin ecNumber "3.4.23.-".
- Presenilin entrezgene "5663".
- Presenilin entrezgene "5664".
- Presenilin hgncid "9508".
- Presenilin hgncid "9509".
- Presenilin locusSupplementaryData "-q42".
- Presenilin omim "104311".
- Presenilin omim "600759".
- Presenilin refseq "NM_000021".
- Presenilin refseq "NM_000447".
- Presenilin symbol "AD3".
- Presenilin symbol "AD4".
- Presenilin symbol "PSEN1".
- Presenilin symbol "PSEN2".
- Presenilin symbol "Presenilin".
- Presenilin thumbnail 2KR6.pdb.png?width=300.
- Presenilin uniprot "P49768".
- Presenilin uniprot "P49810".
- Presenilin wikiPageExternalLink merops.cgi?id=A22.001.
- Presenilin wikiPageExternalLink merops.cgi?id=A22.002.
- Presenilin wikiPageExternalLink www.dian-info.org.
- Presenilin wikiPageExternalLink www.dianer.org.
- Presenilin wikiPageExternalLink explore.do?structureId=2KR6.
- Presenilin wikiPageID "7732070".
- Presenilin wikiPageRevisionID "592846419".
- Presenilin altsymbols "AD3".
- Presenilin altsymbols "AD4".
- Presenilin arm "q".
- Presenilin band "24.3".
- Presenilin band "31".
- Presenilin caption "Solution structure of the human presenilin-1 CTF subunit.".
- Presenilin chromosome "1".
- Presenilin chromosome "14".
- Presenilin ecnumber "3.4".
- Presenilin entrezgene "5663".
- Presenilin entrezgene "5664".
- Presenilin hasPhotoCollection Presenilin.
- Presenilin hgncid "9508".
- Presenilin hgncid "9509".
- Presenilin interpro "IPR001108".
- Presenilin locussupplementarydata "-q42".
- Presenilin merops "A22".
- Presenilin name PSEN1.
- Presenilin name PSEN2.
- Presenilin name "Presenilin".
- Presenilin omim "104311".
- Presenilin omim "600759".
- Presenilin opmFamily "277".
- Presenilin opmProtein "4".
- Presenilin pfam "PF01080".
- Presenilin pfamClan "CL0130".
- Presenilin refseq "NM_000021".
- Presenilin refseq "NM_000447".
- Presenilin symbol PSEN1.
- Presenilin symbol PSEN2.
- Presenilin symbol "Presenilin".
- Presenilin tcdb "1".
- Presenilin uniprot "P49768".
- Presenilin uniprot "P49810".
- Presenilin subject Category:Moonlighting_proteins.
- Presenilin type Abstraction100002137.
- Presenilin type Chemical114806838.
- Presenilin type Compound114818238.
- Presenilin type Macromolecule114944888.
- Presenilin type Material114580897.
- Presenilin type Matter100020827.
- Presenilin type Molecule114682133.
- Presenilin type MoonlightingProteins.
- Presenilin type OrganicCompound114727670.
- Presenilin type Part113809207.
- Presenilin type PhysicalEntity100001930.
- Presenilin type Protein114728724.
- Presenilin type Relation100031921.
- Presenilin type Substance100019613.
- Presenilin type Thing100002452.
- Presenilin type Unit109465459.
- Presenilin type Biomolecule.
- Presenilin type Protein.
- Presenilin type ProteinMolecule.
- Presenilin type BiologicalObject.
- Presenilin comment "Presenilins are a family of related multi-pass transmembrane proteins that function as a part of the gamma-secretase intramembrane protease complex. They were first identified in screens for mutations causing early onset forms of familial Alzheimer's Disease by Peter St George-Hyslop at the Centre for Research in Neurodegenerative Diseases at the University of Toronto, and now also at the University of Cambridge.".
- Presenilin label "Presenilin".
- Presenilin label "Präseniline".
- Presenilin label "Пресенилин".
- Presenilin sameAs Präseniline.
- Presenilin sameAs m.026b7k4.
- Presenilin sameAs Q907198.
- Presenilin sameAs Q907198.
- Presenilin sameAs Presenilin.
- Presenilin wasDerivedFrom Presenilin?oldid=592846419.
- Presenilin depiction 2KR6.pdb.png.
- Presenilin isPrimaryTopicOf Presenilin.
- Presenilin name "presenilin 1(Alzheimer's disease 3)".
- Presenilin name "presenilin 2(Alzheimer's disease 4)".
