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- Protein_detoxification abstract "Protein detoxification is the process by which proteins containing methylated arginine are broken down and removed from the body.Arginine (Arg) is a non-essential amino acid and one of the most commonly occurring natural amino acids. Methylated arginine is a modified version of arginine that is commonly formed from protein arginine (arginine incorporated in protein). Asymmetrically methylated forms of arginine are toxic when released during protein turnover.The protein detoxification pathway eliminates free methylated-arginine derivatives from the cell. Symmetrically methylated forms are not toxic and are excreted unchanged by the kidney. Asymmetrically methylated forms however are toxic and must first be broken down. This step requires the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Impairment of DDAH function slows breakdown and increases the level of toxic asymmetrically methylated arginine forms.Long term exposure to these toxic amino acids is associated with endothelial dysfunction, arterial stiffness, insulin resistance, chronic kidney disease, heart disease, dementia and ageing.Therapeutic strategies that target the protein detoxification pathway aim to: reduce intracellular levels of free asymmetrically methylated arginine derivatives, slow the ageing process delay the development of disorders associated with ageing.".
- Protein_detoxification thumbnail Protein_detoxification_pathway.jpg?width=300.
- Protein_detoxification wikiPageExternalLink www.allaboutadma.com.
- Protein_detoxification wikiPageExternalLink www.kirribillimedical.com.
- Protein_detoxification wikiPageID "27715927".
- Protein_detoxification wikiPageRevisionID "532099187".
- Protein_detoxification align "left".
- Protein_detoxification alt "Pulsatile flow".
- Protein_detoxification alt "Vascular endothelium".
- Protein_detoxification caption "Shear stress in micro-circulation as a result of arterial stiffness".
- Protein_detoxification caption "Vascular endothelium".
- Protein_detoxification footer "Endothelial dysfunction associated inhibtion of eNOS, reduced NO and vasoconstriction is associated with arterial stiffness. Increased pulse pressure drives arterial pulsations further down the arterial tree, increasing shear stress.".
- Protein_detoxification hasPhotoCollection Protein_detoxification.
- Protein_detoxification image "Endothelium.jpg".
- Protein_detoxification image "Pulsatile flow.jpg".
- Protein_detoxification width "500".
- Protein_detoxification subject Category:Detoxification.
- Protein_detoxification comment "Protein detoxification is the process by which proteins containing methylated arginine are broken down and removed from the body.Arginine (Arg) is a non-essential amino acid and one of the most commonly occurring natural amino acids. Methylated arginine is a modified version of arginine that is commonly formed from protein arginine (arginine incorporated in protein).".
- Protein_detoxification label "Protein detoxification".
- Protein_detoxification sameAs m.0cc8_56.
- Protein_detoxification sameAs Q7251464.
- Protein_detoxification sameAs Q7251464.
- Protein_detoxification wasDerivedFrom Protein_detoxification?oldid=532099187.
- Protein_detoxification depiction Protein_detoxification_pathway.jpg.
- Protein_detoxification isPrimaryTopicOf Protein_detoxification.
