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- Protein_function_prediction abstract "Protein function prediction methods are used to assign biological or biochemical roles to proteins that are poorly studied or predicted proteins based on genomic sequence data. These predictions are often driven by data-intensive computational procedures. Sources of information may come from nucleic acid sequence homology, gene expression profiles, protein domain structures, text mining of publications, phylogenetic profiles, phenotypic profiles, and protein-protein interaction. Protein function is a broad term: the roles of proteins range from catalysis of biochemical reactions to transport to signal transduction, and a single protein may play a role in multiple processes or cellular pathways. Generally, function can be thought of as, "anything that happens to or through a protein". The Gene Ontology Consortium provides a useful classification of functions, based on a dictionary of well-defined terms divided into three main categories of molecular function, biological process and cellular component. Researchers can query this database with a protein name or accession number to retrieve associated Gene Ontology (GO) terms or annotations based on computational or experimental evidence.While techniques such as microarray analysis, RNA interference, and the yeast two-hybrid system can be used to experimentally demonstrate the function of a protein, advances in sequencing technologies have made the rate at which proteins can be experimentally characterized much slower than the rate at which new sequences become available.Thus, the annotation of new sequences is mostly by prediction through computational methods, as these types of annotation can often be done quickly and for many genes or proteins at once. The first such methods inferred function based on homologous proteins with known functions (homology-based function prediction). The development of context-based and structure based methods have expanded what information can be predicted, and a combination of methods can now be used to get a picture of complete cellular pathways based on sequence data. The importance and prevalence of computational prediction of gene function is underlined by an analysis of 'evidence codes' used by the GO database: as of 2010, 98% of annotations were listed under the code IEA (inferred from electronic annotation) while only 0.6% were based on experimental evidence.".
- Protein_function_prediction wikiPageExternalLink Blast.cgi.
- Protein_function_prediction wikiPageExternalLink Blast.cgi?PROGRAM=blastp&BLAST_PROGRAMS=blastp&PAGE_TYPE=BlastSearch&SHOW_DEFAULTS=on&LINK_LOC=blasthome.
- Protein_function_prediction wikiPageExternalLink pfam.sanger.ac.uk.
- Protein_function_prediction wikiPageExternalLink prosite.expasy.org.
- Protein_function_prediction wikiPageExternalLink raptorx.uchicago.edu.
- Protein_function_prediction wikiPageExternalLink pixie.
- Protein_function_prediction wikiPageExternalLink dcpredictormain.cgi.
- Protein_function_prediction wikiPageExternalLink dcGO.
- Protein_function_prediction wikiPageExternalLink SignalP.
- Protein_function_prediction wikiPageExternalLink CSA.
- Protein_function_prediction wikiPageExternalLink www.genemania.org.
- Protein_function_prediction wikiPageExternalLink www.geneontology.org.
- Protein_function_prediction wikiPageExternalLink home.do.
- Protein_function_prediction wikiPageID "29467449".
- Protein_function_prediction wikiPageRevisionID "604967169".
- Protein_function_prediction hasPhotoCollection Protein_function_prediction.
- Protein_function_prediction subject Category:Bioinformatics.
- Protein_function_prediction comment "Protein function prediction methods are used to assign biological or biochemical roles to proteins that are poorly studied or predicted proteins based on genomic sequence data. These predictions are often driven by data-intensive computational procedures. Sources of information may come from nucleic acid sequence homology, gene expression profiles, protein domain structures, text mining of publications, phylogenetic profiles, phenotypic profiles, and protein-protein interaction.".
- Protein_function_prediction label "Protein function prediction".
- Protein_function_prediction sameAs m.0ds6hqy.
- Protein_function_prediction sameAs Q7251473.
- Protein_function_prediction sameAs Q7251473.
- Protein_function_prediction wasDerivedFrom Protein_function_prediction?oldid=604967169.
- Protein_function_prediction isPrimaryTopicOf Protein_function_prediction.