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- Pulsatile_insulin abstract "Pulsatile insulin, sometimes called metabolic activation therapy, or cellular activation therapy describes in a literal sense the intravenous injection of insulin in pulses versus continuous infusions. Injection of insulin in pulses mimics the physiological secretions of insulin by the pancreas into the portal vein which then drains into the liver. In healthy, non-diabetic individuals, pancreatic secretions of insulin correspond to the intake of food. The pancreas will secrete variable amounts of insulin based upon the amount of food consumed (basically speaking, the more food that is consumed, the more insulin the pancreas will secrete) among other factors. The majority of available experimental evidence suggests a more potent hypoglycemic effect of pulsatile insulin in comparison to continuous insulin infusion. Continuous exposure to insulin and glucagon is known to decrease the hormones’ metabolic effectiveness on glucose production in humans due to the body developing an increased tolerance to the hormones. Down-regulation at the cellular level may partially explain the decreased action of steady-state levels of insulin, while pulsatile hormone secretion may allow recovery of receptor affinity and numbers for insulin. Intermittent intravenous insulin administration with peaks of insulin concentrations may enhance suppression of gluconeogenesis and reduce hepatic glucose production.".
- Pulsatile_insulin wikiPageID "5924517".
- Pulsatile_insulin wikiPageRevisionID "588221626".
- Pulsatile_insulin hasPhotoCollection Pulsatile_insulin.
- Pulsatile_insulin subject Category:Insulin_therapies.
- Pulsatile_insulin type Abstraction100002137.
- Pulsatile_insulin type Act100030358.
- Pulsatile_insulin type Activity100407535.
- Pulsatile_insulin type Care100654885.
- Pulsatile_insulin type Event100029378.
- Pulsatile_insulin type InsulinTherapies.
- Pulsatile_insulin type MedicalCare100657604.
- Pulsatile_insulin type PsychologicalFeature100023100.
- Pulsatile_insulin type Therapy100661091.
- Pulsatile_insulin type Treatment100658082.
- Pulsatile_insulin type Work100575741.
- Pulsatile_insulin type YagoPermanentlyLocatedEntity.
- Pulsatile_insulin comment "Pulsatile insulin, sometimes called metabolic activation therapy, or cellular activation therapy describes in a literal sense the intravenous injection of insulin in pulses versus continuous infusions. Injection of insulin in pulses mimics the physiological secretions of insulin by the pancreas into the portal vein which then drains into the liver. In healthy, non-diabetic individuals, pancreatic secretions of insulin correspond to the intake of food.".
- Pulsatile_insulin label "Pulsatile insulin".
- Pulsatile_insulin sameAs m.0fdtrq.
- Pulsatile_insulin sameAs Q7259621.
- Pulsatile_insulin sameAs Q7259621.
- Pulsatile_insulin sameAs Pulsatile_insulin.
- Pulsatile_insulin wasDerivedFrom Pulsatile_insulin?oldid=588221626.
- Pulsatile_insulin isPrimaryTopicOf Pulsatile_insulin.