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- Purine_analogue abstract "Purine analogues are antimetabolites that mimic the structure of metabolic purines.Azathioprine is the main immunosuppressive cytotoxic substance. It is widely used in transplantations to control rejection reactions. It is nonenzymatically cleaved to 6-mercaptopurine that acts as a purine analogue and an inhibitor of DNA synthesis. By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell and the humoral immunity. It also successfully suppresses autoimmunity.MercaptopurineThiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic leukemiasFludarabine inhibits function of multiple DNA polymerases, DNA primase, and DNA ligase I, and is S phase-specific (since these enzymes are highly active during DNA replication).Pentostatin and cladribine are adenosine analogs that are used primarily to treat hairy cell leukemia.".
- Purine_analogue wikiPageID "17911568".
- Purine_analogue wikiPageRevisionID "600814965".
- Purine_analogue hasPhotoCollection Purine_analogue.
- Purine_analogue subject Category:Antimetabolites.
- Purine_analogue subject Category:Purines.
- Purine_analogue type Abstraction100002137.
- Purine_analogue type Base114618253.
- Purine_analogue type Chemical114806838.
- Purine_analogue type Compound114818238.
- Purine_analogue type Material114580897.
- Purine_analogue type Matter100020827.
- Purine_analogue type Part113809207.
- Purine_analogue type PhysicalEntity100001930.
- Purine_analogue type Purine114706749.
- Purine_analogue type Purines.
- Purine_analogue type Relation100031921.
- Purine_analogue type Substance100019613.
- Purine_analogue comment "Purine analogues are antimetabolites that mimic the structure of metabolic purines.Azathioprine is the main immunosuppressive cytotoxic substance. It is widely used in transplantations to control rejection reactions. It is nonenzymatically cleaved to 6-mercaptopurine that acts as a purine analogue and an inhibitor of DNA synthesis. By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell and the humoral immunity.".
- Purine_analogue label "Purine analogue".
- Purine_analogue label "Антагонисты пуринов".
- Purine_analogue label "嘌呤类似物".
- Purine_analogue sameAs m.047n3d0.
- Purine_analogue sameAs Q6593447.
- Purine_analogue sameAs Q6593447.
- Purine_analogue sameAs Purine_analogue.
- Purine_analogue wasDerivedFrom Purine_analogue?oldid=600814965.
- Purine_analogue isPrimaryTopicOf Purine_analogue.