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- Pyroptosis abstract "Pyroptosis is a form of programmed cell death associated with antimicrobial responses during inflammation. In this process, immune cells that recognize certain danger signals within themselves produce cytokines, swell, burst and die. This releases the cytokines, attracts other immune cells to fight the infection and contributes to inflammation. Pyroptosis occurs for example in salmonella-infected macrophages and in HIV-infected T helper cells.The initiation of pyroptosis is caused by the recognition of flagellin components of Salmonella and Shigella species (and similar pathogen-associated molecular patterns (PAMPs) in other microbial pathogens) by NOD-like receptors (NLRs). These receptors function like plasma membrane Toll-like receptors (TLRs), but recognise antigens located within the cell rather than outside of it.In contrast to apoptosis, pyroptosis requires the function of the enzyme caspase-1. Recently, it was shown that caspase-1 is activated during pyroptosis by a large supramolecular complex termed the pyroptosome (also known as an inflammasome). Only one large pyroptosome is formed in each macrophage, within minutes after infection. Biochemical and Mass Spectroscopic analysis revealed that this pyroptosome is largely composed of dimers of the adaptor protein ASC (apoptosis-associated speck protein containing a CARD or Caspase activation and recruitment domain).Unlike apoptosis, pyroptosis results in the release of pathogen associated molecular patterns (PAMPs) and cytokines that activate pro-inflammatory immune cell mediators.".
- Pyroptosis thumbnail Pyroptosis_mechanism.png?width=300.
- Pyroptosis wikiPageID "8948754".
- Pyroptosis wikiPageRevisionID "602850407".
- Pyroptosis hasPhotoCollection Pyroptosis.
- Pyroptosis subject Category:Programmed_cell_death.
- Pyroptosis comment "Pyroptosis is a form of programmed cell death associated with antimicrobial responses during inflammation. In this process, immune cells that recognize certain danger signals within themselves produce cytokines, swell, burst and die. This releases the cytokines, attracts other immune cells to fight the infection and contributes to inflammation.".
- Pyroptosis label "Pyroptosis".
- Pyroptosis sameAs m.027qv8l.
- Pyroptosis sameAs Q7263707.
- Pyroptosis sameAs Q7263707.
- Pyroptosis wasDerivedFrom Pyroptosis?oldid=602850407.
- Pyroptosis depiction Pyroptosis_mechanism.png.
- Pyroptosis isPrimaryTopicOf Pyroptosis.
