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- REV1 abstract "DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. Rev1 is a Y family DNA polymerase; it is sometimes referred to as a deoxycytidyl transferase because it only inserts deoxycytidine (dC) across from lesions. Whether G, A, T, C, or an abasic site, Rev1 will always add a C. Rev1 has the ability to always add a C, because it uses an arginine as a template which complements well with C. Yet it is believed that Rev1 rarely uses its polymerase activity, rather it is thought that Rev1's primary role is as a protein landing pad, whereby it helps direct the recruitment of TLS proteins, especially Pol ζ (Rev3/Rev7).".
- REV1 entrezgene "51455".
- REV1 wikiPageID "14799438".
- REV1 wikiPageRevisionID "592930441".
- REV1 hasPhotoCollection REV1.
- REV1 requireManualInspection "no".
- REV1 summaryText "This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.".
- REV1 updateCitations "yes".
- REV1 updatePage "yes".
- REV1 updateProteinBox "yes".
- REV1 updateSummary "yes".
- REV1 type Biomolecule.
- REV1 type Protein.
- REV1 type BiologicalObject.
- REV1 comment "DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA.".
- REV1 label "REV1".
- REV1 sameAs m.03gyd5j.
- REV1 sameAs Q7276399.
- REV1 sameAs Q7276399.
- REV1 wasDerivedFrom REV1?oldid=592930441.
- REV1 isPrimaryTopicOf REV1.