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- RNA_interference abstract "RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules. Historically, it was known by other names, including co-suppression, post transcriptional gene silencing (PTGS), and quelling. Only after these apparently unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon. Andrew Fire and Craig C. Mello shared the 2006 Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm Caenorhabditis elegans, which they published in 1998.Two types of small ribonucleic acid (RNA) molecules – microRNA (miRNA) and small interfering RNA (siRNA) – are central to RNA interference. RNAs are the direct products of genes, and these small RNAs can bind to other specific messenger RNA (mRNA) molecules and either increase or decrease their activity, for example by preventing an mRNA from producing a protein. RNA interference has an important role in defending cells against parasitic nucleotide sequences – viruses and transposons. It also influences development.The RNAi pathway is found in many eukaryotes including animals and is initiated by the enzyme Dicer, which cleaves long double-stranded RNA (dsRNA) molecules into short double stranded fragments of ~20 nucleotide siRNAs. Each siRNA is unwound into two single-stranded (ss) ssRNAs, respectively the passenger strand and the guide strand. The passenger strand is degraded and the guide strand is incorporated into the RNA-induced silencing complex (RISC). The most well-studied outcome is post-transcriptional gene silencing, which occurs when the guide strand pairs with a complementary sequence in a messenger RNA molecule and induces cleavage by Argonaute, the catalytic component of the RISC complex. In some organisms, this process spreads systemically, despite the initially limited molar concentrations of siRNA.RNAi is a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. RNAi may be used for large-scale screens that systematically shut down each gene in the cell, which can help to identify the components necessary for a particular cellular process or an event such as cell division. The pathway is also used as a practical tool in biotechnology, medicine and insecticides.".
- RNA_interference thumbnail ShRNA_Lentivirus.svg?width=300.
- RNA_interference wikiPageExternalLink rnaiatlas.ethz.ch.
- RNA_interference wikiPageExternalLink GenomeRNAi.
- RNA_interference wikiPageExternalLink animation.htm.
- RNA_interference wikiPageExternalLink 2008.
- RNA_interference wikiPageExternalLink rnai_screens_in_c_elegans_in_a.php.
- RNA_interference wikiPageExternalLink 03nobel.html?ex=1180065600&en=e26ec371cb398ea0&ei=5070.
- RNA_interference wikiPageExternalLink 02.html.
- RNA_interference wikiPageExternalLink journal.pbio.0020133.
- RNA_interference wikiPageExternalLink www.silencinggenomes.org.
- RNA_interference wikiPageExternalLink rna-interference-explained.
- RNA_interference wikiPageID "29188721".
- RNA_interference wikiPageRevisionID "605772866".
- RNA_interference hasPhotoCollection RNA_interference.
- RNA_interference link journal.pbio.0020133.
- RNA_interference title "Planting the Seeds of a New Paradigm".
- RNA_interference subject Category:Gene_expression.
- RNA_interference subject Category:Molecular_genetics.
- RNA_interference subject Category:RNA.
- RNA_interference subject Category:RNA_interference.
- RNA_interference comment "RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules. Historically, it was known by other names, including co-suppression, post transcriptional gene silencing (PTGS), and quelling. Only after these apparently unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon. Andrew Fire and Craig C.".
- RNA_interference label "ARN interferente".
- RNA_interference label "Interferencja RNA".
- RNA_interference label "Interférence par ARN".
- RNA_interference label "RNA interference".
- RNA_interference label "RNA interference".
- RNA_interference label "RNA interferente".
- RNA_interference label "RNA-Interferenz".
- RNA_interference label "RNA-interferentie".
- RNA_interference label "RNAi".
- RNA_interference label "RNA干扰".
- RNA_interference label "РНК-интерференция".
- RNA_interference label "تداخل الرنا".
- RNA_interference sameAs RNA_interference.
- RNA_interference sameAs RNA-Interferenz.
- RNA_interference sameAs Επεμβατικό_RNA.
- RNA_interference sameAs ARN_interferente.
- RNA_interference sameAs Interférence_par_ARN.
- RNA_interference sameAs Interferensi_RNA.
- RNA_interference sameAs RNA_interference.
- RNA_interference sameAs RNAi.
- RNA_interference sameAs RNA_간섭.
- RNA_interference sameAs RNA-interferentie.
- RNA_interference sameAs Interferencja_RNA.
- RNA_interference sameAs RNA_interferente.
- RNA_interference sameAs m.0xnnb.
- RNA_interference sameAs Q201993.
- RNA_interference sameAs Q201993.
- RNA_interference wasDerivedFrom RNA_interference?oldid=605772866.
- RNA_interference depiction ShRNA_Lentivirus.svg.
- RNA_interference isPrimaryTopicOf RNA_interference.
