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- RTI-371 abstract "3β-(4-methylphenyl)-2β-[3-(4-chlorophenyl)isoxazol-5-yl]tropane (RTI-371) is a phenyltropane derived drug which acts as a potent and selective dopamine reuptake inhibitor in vitro, yet unusually for this class of compound, both RTI-371 and the closely related compound RTI-370 failed to produce locomotor stimulation in mice. In addition to this, in drug substitution tests RTI-370 weakly generalized to cocaine whereas RTI-371 did not generalize at all. This phenomenon has also been observed for other dopamine reuptake inhibitors from other classes. It may be caused by lack of BBB penetration, or interactions at alternative receptor sites. Recently the second of these hypotheses was suggested for this compound when it was discovered that RTI-371 also acts as a positive allosteric modulator of the hCB1 human cannabinoid receptor.".
- RTI-371 casNumber "652978-45-5".
- RTI-371 iupacName "3-(4-chlorophenyl)-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazole".
- RTI-371 pubchem "11474847".
- RTI-371 thumbnail RTI-371_structure.png?width=300.
- RTI-371 wikiPageID "24374124".
- RTI-371 wikiPageRevisionID "501348056".
- RTI-371 c "24".
- RTI-371 casNumber "652978".
- RTI-371 cl "1".
- RTI-371 h "25".
- RTI-371 hasPhotoCollection RTI-371.
- RTI-371 iupacName "3".
- RTI-371 molecularWeight "392.92".
- RTI-371 n "2".
- RTI-371 o "1".
- RTI-371 pubchem "11474847".
- RTI-371 smiles "CC1=CC=C[C@H]2C[C@@H]3CC[C@H]N3C".
- RTI-371 verifiedrevid "424845321".
- RTI-371 width "200".
- RTI-371 subject Category:Dopamine_reuptake_inhibitors.
- RTI-371 subject Category:Isoxazoles.
- RTI-371 subject Category:Organochlorides.
- RTI-371 subject Category:RTI_compounds.
- RTI-371 subject Category:Sympathomimetic_amines.
- RTI-371 subject Category:Tropanes.
- RTI-371 type Drug.
- RTI-371 type DrugProduct.
- RTI-371 type FunctionalSubstance.
- RTI-371 comment "3β-(4-methylphenyl)-2β-[3-(4-chlorophenyl)isoxazol-5-yl]tropane (RTI-371) is a phenyltropane derived drug which acts as a potent and selective dopamine reuptake inhibitor in vitro, yet unusually for this class of compound, both RTI-371 and the closely related compound RTI-370 failed to produce locomotor stimulation in mice. In addition to this, in drug substitution tests RTI-370 weakly generalized to cocaine whereas RTI-371 did not generalize at all.".
- RTI-371 label "RTI-371".
- RTI-371 sameAs m.07sb1gc.
- RTI-371 sameAs Q7277837.
- RTI-371 sameAs Q7277837.
- RTI-371 wasDerivedFrom RTI-371?oldid=501348056.
- RTI-371 depiction RTI-371_structure.png.
- RTI-371 isPrimaryTopicOf RTI-371.
