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- Receptor_editing abstract "Receptor editing is a process that occurs during the maturation of B cells, which are part of the adaptive immune system. This process forms part of central tolerance to attempt to change the specificity of the antigen receptor of self reactive immature B-cells, in order to rescue them from programmed cell death, called apoptosis. It is thought that 20-50% of all peripheral naive B cells have undergone receptor editing making it the most common method of removing self reactive B cells.During maturation in the bone marrow, B cells are tested for interaction with self antigens, which is called negative selection. If the maturing B cells strongly interact with these self antigens, they undergo death by apoptosis. Negative selection is important to avoid the production of B cells that could cause autoimmune diseases. They can avoid apoptosis by modifying the sequence of light chain V and J genes (components of the antigen receptor) so that it has a different specificity and may not recognize self antigens anymore. This process of changing the specificity of the immature B cell receptor is called receptor editing.".
- Receptor_editing wikiPageID "14673055".
- Receptor_editing wikiPageRevisionID "587365032".
- Receptor_editing hasPhotoCollection Receptor_editing.
- Receptor_editing subject Category:Medicine.
- Receptor_editing comment "Receptor editing is a process that occurs during the maturation of B cells, which are part of the adaptive immune system. This process forms part of central tolerance to attempt to change the specificity of the antigen receptor of self reactive immature B-cells, in order to rescue them from programmed cell death, called apoptosis.".
- Receptor_editing label "Receptor editing".
- Receptor_editing sameAs m.03gslvn.
- Receptor_editing sameAs Q7302368.
- Receptor_editing sameAs Q7302368.
- Receptor_editing wasDerivedFrom Receptor_editing?oldid=587365032.
- Receptor_editing isPrimaryTopicOf Receptor_editing.