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- Renin_inhibitor abstract "Renin inhibitors are a group of pharmaceutical drugs used primarily in treatment of essential hypertension (high blood pressure).These drugs inhibit the first and rate-limiting step of the renin-angiotensin-aldosterone system (RAAS), namely the conversion of angiotensinogen to angiotensin I. Since the 1970s, scientists have been trying to develop potent inhibitors with acceptable oral bioavailability. The process was difficult and took about three decades. The first and second generations faced problems such as poor bioavailability and lack of potency. Finally, the third generation was discovered. These compounds were nonpeptidic renin inhibitors, had acceptable oral bioavailability and were potent enough for clinical use. The first drug in this class was aliskiren, which received a marketing approval in 2007. As of January 2012, it is the only renin inhibitor on the market.".
- Renin_inhibitor thumbnail Aliskiren.svg?width=300.
- Renin_inhibitor wikiPageExternalLink 21094.php.
- Renin_inhibitor wikiPageID "14778970".
- Renin_inhibitor wikiPageRevisionID "605474381".
- Renin_inhibitor alt "Aliskiren".
- Renin_inhibitor atcPrefix "C09XA".
- Renin_inhibitor biologicalTarget Renin.
- Renin_inhibitor caption "Aliskiren, the first renin inhibitor to be marketed".
- Renin_inhibitor date "October 2011".
- Renin_inhibitor failed "y".
- Renin_inhibitor hasPhotoCollection Renin_inhibitor.
- Renin_inhibitor use Hypertension.
- Renin_inhibitor subject Category:Articles_created_via_the_Article_Wizard.
- Renin_inhibitor subject Category:Renin_inhibitors.
- Renin_inhibitor type Inhibitor114724436.
- Renin_inhibitor type Matter100020827.
- Renin_inhibitor type PhysicalEntity100001930.
- Renin_inhibitor type ReninInhibitors.
- Renin_inhibitor type Substance100020090.
- Renin_inhibitor comment "Renin inhibitors are a group of pharmaceutical drugs used primarily in treatment of essential hypertension (high blood pressure).These drugs inhibit the first and rate-limiting step of the renin-angiotensin-aldosterone system (RAAS), namely the conversion of angiotensinogen to angiotensin I. Since the 1970s, scientists have been trying to develop potent inhibitors with acceptable oral bioavailability. The process was difficult and took about three decades.".
- Renin_inhibitor label "Renin inhibitor".
- Renin_inhibitor label "Renininhibitor".
- Renin_inhibitor label "Рениновый рецептор".
- Renin_inhibitor label "مثبطات الرينين".
- Renin_inhibitor sameAs Renininhibitor.
- Renin_inhibitor sameAs m.03gxr9j.
- Renin_inhibitor sameAs Q409255.
- Renin_inhibitor sameAs Q409255.
- Renin_inhibitor sameAs Renin_inhibitor.
- Renin_inhibitor wasDerivedFrom Renin_inhibitor?oldid=605474381.
- Renin_inhibitor depiction Aliskiren.svg.
- Renin_inhibitor isPrimaryTopicOf Renin_inhibitor.
