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- Repoxygen abstract "Repoxygen is the tradename for a type of gene therapy that induces controlled release of erythropoietin (EPO) in response to low oxygen concentration. It has been developed by Oxford Biomedica to treat anaemia. It has been developed in mice, is still in preclinical development and has not been extensively tested in humans.It is constructed as a viral gene delivery vector carrying the human EPO gene under the control of a so-called "hypoxia control element" (“HRE”). The HRE is claimed to sense low oxygen concentrations and to switch a gene on in response. Repoxygen is designed to be delivered by injection into muscle and therefore to induce syntheses of EPO in the muscle tissue. Normally, EPO is synthesized in the liver and kidneys. It leads to increased production of red blood cells.Use of recombinate EPO DNA in mice has shown protective effects for epithelial cells and is being investigated as a prophylatic treatment for lung tissue injury.Excess EPO, the signalling hormone for more red blood cell production (increased erythrocytes), can lead to erythrocytosis—a condition of too many red blood cells. Erythrocytosis makes the blood thicker and more viscous, making pooling and clotting more likely, and represents an increased stress on the heart (due to the thicker blood). Erythrocytosis is potentially fatal, especially in endurance athletes who are frequently dehydrated during long events.".
- Repoxygen wikiPageExternalLink Finding_the_golden_genes.
- Repoxygen wikiPageID "3869631".
- Repoxygen wikiPageRevisionID "544279271".
- Repoxygen hasPhotoCollection Repoxygen.
- Repoxygen subject Category:Applied_genetics.
- Repoxygen subject Category:Doping_in_sport.
- Repoxygen subject Category:Medical_genetics.
- Repoxygen comment "Repoxygen is the tradename for a type of gene therapy that induces controlled release of erythropoietin (EPO) in response to low oxygen concentration. It has been developed by Oxford Biomedica to treat anaemia. It has been developed in mice, is still in preclinical development and has not been extensively tested in humans.It is constructed as a viral gene delivery vector carrying the human EPO gene under the control of a so-called "hypoxia control element" (“HRE”).".
- Repoxygen label "Repoxygen".
- Repoxygen label "Repoxygen".
- Repoxygen sameAs Repoxygen.
- Repoxygen sameAs m.0b46p0.
- Repoxygen sameAs Q113943.
- Repoxygen sameAs Q113943.
- Repoxygen wasDerivedFrom Repoxygen?oldid=544279271.
- Repoxygen isPrimaryTopicOf Repoxygen.