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- Repressor_lexA abstract "Repressor LexA or LexA is a repressor enzyme (EC 3.4.21.88) that represses SOS response genes coding for DNA polymerases required for repairing DNA damage. LexA is intimately linked to RecA in the biochemical cycle of DNA damage and repair. RecA binds to DNA-bound LexA causing LexA to cleave itself in a process called autoproteolysis.DNA damage can be inflicted by the action of antibiotics. Bacteria require topoisomerases such as DNA gyrase or topoisomerase IV for DNA replication. Antibiotics such as ciprofloxacin are able to prevent the action of these molecules by attaching themselves to the gyrase - DNA complex. This is counteracted by the polymerase repair molecules from the SOS response. Unfortunately the action is partly counterproductive because ciprofloxacin is also involved in the synthetic pathway to RecA type molecules which means that the bacteria responds to an antibiotic by starting to produce more repair proteins. These repair proteins can lead to eventual benevolent mutations which can render the bacteria resistant to ciprofloxacin. Mutations are traditionally thought of as happening as a random process and as a liability to the organism. Many strategies exist in a cell to curb the rate of mutations. Mutations on the other hand can also be part of a survival strategy. For the bacteria under attack from an antibiotic, mutations help to develop the right biochemistry needed for defense. Certain polymerases in the SOS pathway are error-prone in their copying of DNA which leads to mutations. While these mutations are often lethal to the cell, they can also lead to mutations which improve the bacteria's survival. In the specific case of topoisomerases, some bacteria have mutated one of their amino acids so that the ciproflaxin can only create a weak bond to the topoisomerase. This is one of the methods that bacteria use to become resistant to antibiotics.Impaired LexA proteolysis has been shown to interfere with ciprofloxacin resistance. This offers potential for combination therapy that combine quinolones with strategies aimed at interfering with the action of LexA either directly, or via RecA. LexA contains a DNA binding domain, this is a variant form of the helix-turn-helix DNA binding motif. it is usually located at the N-terminus of the protein.".
- Repressor_lexA symbol "LexA_DNA_bind".
- Repressor_lexA thumbnail PDB_1jhh_EBI.jpg?width=300.
- Repressor_lexA wikiPageID "1910927".
- Repressor_lexA wikiPageRevisionID "592917154".
- Repressor_lexA caption "lexa s119a mutant".
- Repressor_lexA hasPhotoCollection Repressor_lexA.
- Repressor_lexA interpro "IPR006199".
- Repressor_lexA name "LexA DNA binding domain".
- Repressor_lexA pfam "PF01726".
- Repressor_lexA pfamClan "CL0123".
- Repressor_lexA scop "1".
- Repressor_lexA symbol "LexA_DNA_bind".
- Repressor_lexA subject Category:Bacterial_proteins.
- Repressor_lexA subject Category:DNA_replication.
- Repressor_lexA subject Category:EC_3.4.21.
- Repressor_lexA subject Category:Protein_domains.
- Repressor_lexA type Abstraction100002137.
- Repressor_lexA type Attribute100024264.
- Repressor_lexA type BacterialProteins.
- Repressor_lexA type Chemical114806838.
- Repressor_lexA type Compound114818238.
- Repressor_lexA type Environment113934596.
- Repressor_lexA type Macromolecule114944888.
- Repressor_lexA type Material114580897.
- Repressor_lexA type Matter100020827.
- Repressor_lexA type Molecule114682133.
- Repressor_lexA type OrganicCompound114727670.
- Repressor_lexA type Part113809207.
- Repressor_lexA type PhysicalEntity100001930.
- Repressor_lexA type Protein114728724.
- Repressor_lexA type ProteinDomains.
- Repressor_lexA type Relation100031921.
- Repressor_lexA type Situation113927383.
- Repressor_lexA type Sphere114514039.
- Repressor_lexA type State100024720.
- Repressor_lexA type Substance100019613.
- Repressor_lexA type Thing100002452.
- Repressor_lexA type Unit109465459.
- Repressor_lexA type Biomolecule.
- Repressor_lexA type Protein.
- Repressor_lexA type BiologicalObject.
- Repressor_lexA comment "Repressor LexA or LexA is a repressor enzyme (EC 3.4.21.88) that represses SOS response genes coding for DNA polymerases required for repairing DNA damage. LexA is intimately linked to RecA in the biochemical cycle of DNA damage and repair. RecA binds to DNA-bound LexA causing LexA to cleave itself in a process called autoproteolysis.DNA damage can be inflicted by the action of antibiotics. Bacteria require topoisomerases such as DNA gyrase or topoisomerase IV for DNA replication.".
- Repressor_lexA label "Repressor lexA".
- Repressor_lexA sameAs m.065k8t.
- Repressor_lexA sameAs Q7314274.
- Repressor_lexA sameAs Q7314274.
- Repressor_lexA sameAs Repressor_lexA.
- Repressor_lexA wasDerivedFrom Repressor_lexA?oldid=592917154.
- Repressor_lexA depiction PDB_1jhh_EBI.jpg.
- Repressor_lexA isPrimaryTopicOf Repressor_lexA.
