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- Reserpine abstract "Reserpine (Lannett's Serpalan) is an indole alkaloid, antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance.Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). However, this claim is not without controversy. The reserpine-induced depression is considered by some researchers to be a myth, while others claim that teas made out of the plant roots containing reserpine have a calming, sedative action that can actually be considered antidepressant. Notably, reserpine was the first compound shown to be an effective antidepressant in a randomized placebo-controlled trial.Moreover, reserpine has a peripheral action in many parts of the body, resulting in a preponderance of the effects of the cholinergic part of the autonomous nervous system on the GI tract, smooth muscles, blood vessels, etc.".
- Reserpine atcPrefix "C02".
- Reserpine atcSuffix "AA02".
- Reserpine bioavailability "50.0".
- Reserpine casNumber "50-55-5".
- Reserpine chEBI "28487".
- Reserpine drugbank "DB00206".
- Reserpine fdaUniiCode "8B1QWR724A".
- Reserpine iupacName "''Methyl (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate".
- Reserpine pubchem "5770".
- Reserpine thumbnail Reserpine.png?width=300.
- Reserpine wikiPageExternalLink Synonyms.
- Reserpine wikiPageExternalLink r?dbs+hsdb:@term+@rn+@rel+50-55-5.
- Reserpine wikiPageExternalLink 01May.shtm.
- Reserpine wikiPageID "1480766".
- Reserpine wikiPageRevisionID "604730538".
- Reserpine atcPrefix "2.0".
- Reserpine atcSuffix "AA02".
- Reserpine bioavailability "50.0".
- Reserpine c "33".
- Reserpine casNumber "50".
- Reserpine chebi "28487".
- Reserpine chembl "772".
- Reserpine chemspiderid "5566".
- Reserpine drugbank "DB00206".
- Reserpine eliminationHalfLife "118800.0".
- Reserpine eliminationHalfLife "16200.0".
- Reserpine eliminationHalfLife "975600.0".
- Reserpine exactMass "608.27283".
- Reserpine excretion "62".
- Reserpine h "40".
- Reserpine hasPhotoCollection Reserpine.
- Reserpine inchi "1".
- Reserpine inchikey "QEVHRUUCFGRFIF-MDEJGZGSBW".
- Reserpine iupacName "''Methyl -11,17-dimethoxy-18-[oxy]yohimban-16-carboxylate".
- Reserpine kegg "D00197".
- Reserpine legalStatus "Rx-only".
- Reserpine licenceUs "Reserpine".
- Reserpine medlineplus "a601107".
- Reserpine metabolism "gut/liver".
- Reserpine molecularWeight "608.68".
- Reserpine n "2".
- Reserpine o "9".
- Reserpine pregnancyCategory "C Risk cannot be ruled out, US".
- Reserpine pubchem "5770".
- Reserpine routesOfAdministration "oral".
- Reserpine smiles "O=C[C@H]6[C@H]4C[C@@H]3c2nc1ccccc1c2CCN3C[C@H]4C[C@@H][C@@H]6OC".
- Reserpine stdinchi "1".
- Reserpine stdinchikey "QEVHRUUCFGRFIF-MDEJGZGSSA-N".
- Reserpine unii "8".
- Reserpine verifiedrevid "460779417".
- Reserpine watchedfields "changed".
- Reserpine width "350".
- Reserpine subject Category:Alkaloids_found_in_Rauvolfia.
- Reserpine subject Category:Antihypertensive_agents.
- Reserpine subject Category:Benzoates.
- Reserpine subject Category:Depressogenics.
- Reserpine subject Category:Fetotoxins.
- Reserpine subject Category:Indole_alkaloids.
- Reserpine subject Category:Phenol_ethers.
- Reserpine subject Category:VMAT_inhibitors.
- Reserpine type Drug.
- Reserpine type DrugProduct.
- Reserpine type FunctionalSubstance.
- Reserpine comment "Reserpine (Lannett's Serpalan) is an indole alkaloid, antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today.".
- Reserpine label "Reserpin".
- Reserpine label "Reserpina".
- Reserpine label "Reserpina".
- Reserpine label "Reserpina".
- Reserpine label "Reserpine".
- Reserpine label "Reserpine".
- Reserpine label "Rezerpina".
- Reserpine label "Réserpine".
- Reserpine label "Резерпин".
- Reserpine label "レセルピン".
- Reserpine label "利血平".
- Reserpine sameAs Reserpin.
- Reserpine sameAs Reserpina.
- Reserpine sameAs Réserpine.
- Reserpine sameAs Reserpina.
- Reserpine sameAs レセルピン.
- Reserpine sameAs Reserpine.
- Reserpine sameAs Rezerpina.
- Reserpine sameAs Reserpina.
- Reserpine sameAs m.054vrz.
- Reserpine sameAs Q407841.
- Reserpine sameAs Q407841.
- Reserpine sameAs Reserpine.
- Reserpine sameAs DB00206.
- Reserpine sameAs 5052.
- Reserpine wasDerivedFrom Reserpine?oldid=604730538.
- Reserpine depiction Reserpine.png.
- Reserpine isPrimaryTopicOf Reserpine.