Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Retroviral_Psi_packaging_element> ?p ?o. }
Showing items 1 to 47 of
47
with 100 items per page.
- Retroviral_Psi_packaging_element abstract "Retroviral Psi packaging element is a cis-acting RNA element identified in the genomes of the retroviruses Human immunodeficiency virus (HIV) and Simian immunodeficiency virus (SIV). It is involved in regulating the essential process of packaging the retroviral RNA genome into the viral capsid during replication. The final virion contains a dimer of two identical unspliced copies of the viral genome.In HIV, the Psi element is ∼80–150 nucleotides in length, and located at the 5' end of the genome just upstream of the gag initiation codon. It has a known secondary structure composed of four hairpins called SL1 to SL4 (SL is for Stem-loop) which are connected by relatively short linkers. All four stem loops are important for genome packaging and each of the stem loops SL1, SL2, SL3 and SL4 has been independently expressed and structurally characterised.Stem loop 1 (SL1) (also referred to as HIV-1_DIS) consists of a conserved hairpin structure with a palindromic loop sequence which was predicted and confirmed by mutagenesis. This palindromic loop is known as the primary dimer initiation site (DIS) as it is believed to promote dimerization of the viral genome through formation of a "kissing dimer" intermediate. The Rfam structure shown is based on a covariation model.It has been shown that SL1 may provide a secondary binding site for the viral Rev protein. The Rev protein is an essential HIV regulatory protein which increases the stability and transport of the unspliced viral RNA.Stem-loop 2 (SL2) (also referred to as HIV-1 SD) consists of a highly conserved 19 nt stem-loop which has been shown by mutatagenis to modulate the splicing efficiency of HIV-1 mRNAs.Stem-loop 3 (SL3) consists of a highly conserved 14 nt stem-loop which was predicted and confirmed by mutagenesis and mass spectrometric detection (MS3D). HIV-1 SL3 is sufficient by itself to induce heterologous RNA into virus-like particles but its deletion does not completely eliminate encapsidation.Stem-loop 4 (SL4) consists of a highly conserved 14 nt stem-loop that is located just downstream of the gag start codon. The structure was confirmed by mutagenesis and has an NMR and mass spectrometric detection (MS3D). It also may have coding and non-coding roles.".
- Retroviral_Psi_packaging_element thumbnail RF00175.jpg?width=300.
- Retroviral_Psi_packaging_element wikiPageExternalLink rfam.sanger.ac.uk.
- Retroviral_Psi_packaging_element wikiPageExternalLink RF01380.
- Retroviral_Psi_packaging_element wikiPageExternalLink RF01381.
- Retroviral_Psi_packaging_element wikiPageExternalLink RF01382.
- Retroviral_Psi_packaging_element wikiPageID "11421408".
- Retroviral_Psi_packaging_element wikiPageRevisionID "545293752".
- Retroviral_Psi_packaging_element altsymbols "Retroviral_psi".
- Retroviral_Psi_packaging_element caption "Predicted secondary structure and sequence conservation of HIV-1_DIS".
- Retroviral_Psi_packaging_element hasPhotoCollection Retroviral_Psi_packaging_element.
- Retroviral_Psi_packaging_element id "RF00175".
- Retroviral_Psi_packaging_element id "RF01380".
- Retroviral_Psi_packaging_element id "RF01381".
- Retroviral_Psi_packaging_element id "RF01382".
- Retroviral_Psi_packaging_element name "HIV-1 SL3".
- Retroviral_Psi_packaging_element name "HIV-1 SL4".
- Retroviral_Psi_packaging_element name "HIV-1_DIS".
- Retroviral_Psi_packaging_element name "HIV-1_SD".
- Retroviral_Psi_packaging_element name "Human immunodeficiency virus type 1 dimerisation initiation site".
- Retroviral_Psi_packaging_element name "hide the gallery".
- Retroviral_Psi_packaging_element rfam "RF00175".
- Retroviral_Psi_packaging_element rnaType Cis-regulatory_element.
- Retroviral_Psi_packaging_element state "autocollapse".
- Retroviral_Psi_packaging_element symbol "HIV-1_DIS".
- Retroviral_Psi_packaging_element taxDomain "Viruses".
- Retroviral_Psi_packaging_element title "Gallery of HIV-1 Psi element stem loops 2-4".
- Retroviral_Psi_packaging_element titlestyle "background:#e7dcc3".
- Retroviral_Psi_packaging_element subject Category:Cis-regulatory_RNA_elements.
- Retroviral_Psi_packaging_element type Abstraction100002137.
- Retroviral_Psi_packaging_element type Cis-regulatoryRNAElements.
- Retroviral_Psi_packaging_element type Cognition100023271.
- Retroviral_Psi_packaging_element type Component105868954.
- Retroviral_Psi_packaging_element type Concept105835747.
- Retroviral_Psi_packaging_element type Content105809192.
- Retroviral_Psi_packaging_element type Idea105833840.
- Retroviral_Psi_packaging_element type Part105867413.
- Retroviral_Psi_packaging_element type PsychologicalFeature100023100.
- Retroviral_Psi_packaging_element comment "Retroviral Psi packaging element is a cis-acting RNA element identified in the genomes of the retroviruses Human immunodeficiency virus (HIV) and Simian immunodeficiency virus (SIV). It is involved in regulating the essential process of packaging the retroviral RNA genome into the viral capsid during replication.".
- Retroviral_Psi_packaging_element label "Retroviral Psi packaging element".
- Retroviral_Psi_packaging_element sameAs m.02rbzz_.
- Retroviral_Psi_packaging_element sameAs Q7317090.
- Retroviral_Psi_packaging_element sameAs Q7317090.
- Retroviral_Psi_packaging_element sameAs Retroviral_Psi_packaging_element.
- Retroviral_Psi_packaging_element wasDerivedFrom Retroviral_Psi_packaging_element?oldid=545293752.
- Retroviral_Psi_packaging_element depiction RF00175.jpg.
- Retroviral_Psi_packaging_element isPrimaryTopicOf Retroviral_Psi_packaging_element.
