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- Reverse_transcriptase abstract "Reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. RT is needed for the replication of retroviruses (e.g., HIV), and RT inhibitors are widely used as antiretroviral drugs. RT activity is also associated with the replication of chromosome ends (telomerase) and some mobile genetic elements (retrotransposons).Retroviral RT has three sequential biochemical activities: (a) RNA-dependent DNA polymerase, (b) ribonuclease H, and (c) DNA-dependent DNA polymerase. These activities are used by the retrovirus to convert single-stranded genomic RNA into double-stranded cDNA which can integrate into the host genome, potentially generating a long-term infection that can be very difficult to eradicate. The same sequence of reactions is widely used in the laboratory to convert RNA to DNA for use in molecular cloning, RNA sequencing, polymerase chain reaction (PCR), or genome analysis.Well studied reverse transcriptases include: HIV-1 reverse transcriptase from human immunodeficiency virus type 1 (PDB 1HMV) M-MLV reverse transcriptase from the Moloney murine leukemia virus AMV reverse transcriptase from the avian myeloblastosis virus Telomerase reverse transcriptase that maintains the telomeres of eukaryotic chromosomes↑".
- Reverse_transcriptase symbol "RVT_1".
- Reverse_transcriptase thumbnail Reverse_Transcriptase_1HMV.png?width=300.
- Reverse_transcriptase wikiPageExternalLink motm.do?momID=33.
- Reverse_transcriptase wikiPageExternalLink pdb33_1.html.
- Reverse_transcriptase wikiPageExternalLink bgdisplay.jhtml?itemname=HIV_discovery&product=none&s=2.
- Reverse_transcriptase wikiPageExternalLink watch?v=RO8MP3wMvqg.
- Reverse_transcriptase wikiPageID "26214".
- Reverse_transcriptase wikiPageRevisionID "594610223".
- Reverse_transcriptase caption "Crystallographic structure of HIV reverse transcriptase where the P51 subunit is colored green and the P66 subunit is colored cyan.".
- Reverse_transcriptase casNumber "9068".
- Reverse_transcriptase cdd "cd00304".
- Reverse_transcriptase ecNumber "2.7".
- Reverse_transcriptase goCode "3964".
- Reverse_transcriptase hasPhotoCollection Reverse_transcriptase.
- Reverse_transcriptase interpro "IPR000477".
- Reverse_transcriptase iubmbEcNumber "2".
- Reverse_transcriptase name "RNA-directed DNA polymerase".
- Reverse_transcriptase name "Reverse transcriptase".
- Reverse_transcriptase pfam "PF00078".
- Reverse_transcriptase pfamClan "CL0027".
- Reverse_transcriptase prosite "PS50878".
- Reverse_transcriptase scop "1".
- Reverse_transcriptase symbol "RVT_1".
- Reverse_transcriptase subject Category:EC_2.7.7.
- Reverse_transcriptase subject Category:Genetics.
- Reverse_transcriptase subject Category:Molecular_biology.
- Reverse_transcriptase subject Category:Telomeres.
- Reverse_transcriptase subject Category:Viral_enzymes.
- Reverse_transcriptase type Biomolecule.
- Reverse_transcriptase type Protein.
- Reverse_transcriptase type BiologicalObject.
- Reverse_transcriptase comment "Reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. RT is needed for the replication of retroviruses (e.g., HIV), and RT inhibitors are widely used as antiretroviral drugs.".
- Reverse_transcriptase label "DNA polimerasi (RNA-dipendente)".
- Reverse_transcriptase label "Odwrotna transkryptaza".
- Reverse_transcriptase label "Reverse Transkriptase".
- Reverse_transcriptase label "Reverse transcriptase".
- Reverse_transcriptase label "Reverse-transcriptase".
- Reverse_transcriptase label "Transcriptasa inversa".
- Reverse_transcriptase label "Transcriptase inverse".
- Reverse_transcriptase label "Transcriptase reversa".
- Reverse_transcriptase label "Обратная транскриптаза".
- Reverse_transcriptase label "منتسخة عكسية".
- Reverse_transcriptase label "逆転写酵素".
- Reverse_transcriptase label "逆转录酶".
- Reverse_transcriptase sameAs Reverzní_transkriptáza.
- Reverse_transcriptase sameAs Reverse_Transkriptase.
- Reverse_transcriptase sameAs Αντίστροφη_μεταγραφάση.
- Reverse_transcriptase sameAs Transcriptasa_inversa.
- Reverse_transcriptase sameAs Transcriptase_inverse.
- Reverse_transcriptase sameAs Transkriptase_balik.
- Reverse_transcriptase sameAs DNA_polimerasi_(RNA-dipendente).
- Reverse_transcriptase sameAs 逆転写酵素.
- Reverse_transcriptase sameAs 역전사_효소.
- Reverse_transcriptase sameAs Reverse-transcriptase.
- Reverse_transcriptase sameAs Odwrotna_transkryptaza.
- Reverse_transcriptase sameAs Transcriptase_reversa.
- Reverse_transcriptase sameAs m.06jmk.
- Reverse_transcriptase sameAs Q28774.
- Reverse_transcriptase sameAs Q28774.
- Reverse_transcriptase sameAs 2647.
- Reverse_transcriptase wasDerivedFrom Reverse_transcriptase?oldid=594610223.
- Reverse_transcriptase depiction Reverse_Transcriptase_1HMV.png.
- Reverse_transcriptase isPrimaryTopicOf Reverse_transcriptase.
