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- Rintatolimod abstract "Rintatolimod (tradename Ampligen, also known as poly I:poly C12U), is an experimental immunomodulatory double stranded RNA drug developed by Hemispherx Biopharma of Philadelphia, Pennsylvania. Rintatolimod was first synthesized in the 1970s and has been proposed and tested as a treatment for illnesses including chronic fatigue syndrome (CFS) and acquired immunodeficiency syndrome (AIDS).Hemispherx reports that it completed a Phase III clinical trial for CFS in 2004.[citation needed] In 2007 it filed a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) to market and sell rintatolimod for the treatment of CFS, but this was rejected in December 2009 because the FDA concluded that the two RCTs "did not provide credible evidence of efficacy" and "because of clinical, statistical, clinical pharmacology, nonclinical, product quality, and facilities inspection deficiencies." The FDA requested Hemispherx conduct at least one additional controlled trial to demonstrate efficacy in treating CFS. In August 2012 Hemispherx submitted further analyses of the original clinical trial data, although did not submit additional trials for review. Four months later a committee of the FDA voted 8-5 against approval for Ampligen, again citing "insufficient safety and efficacy data."".
- Rintatolimod atcPrefix "none".
- Rintatolimod casNumber "38640-92-5".
- Rintatolimod fdaUniiCode "94325AJ25N".
- Rintatolimod iupacName "5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid polymer with 5'-uridylic acid (1:1)".
- Rintatolimod wikiPageExternalLink ampligen.html.
- Rintatolimod wikiPageExternalLink ampligen.htm.
- Rintatolimod wikiPageExternalLink kitei.htm.
- Rintatolimod wikiPageExternalLink EST.do.
- Rintatolimod wikiPageExternalLink drug_candidates.htm.
- Rintatolimod wikiPageExternalLink AMP_502.pdf.
- Rintatolimod wikiPageExternalLink ampligen.
- Rintatolimod wikiPageExternalLink browse-edgar?action=getcompany&CIK=0000946644&owner=include.
- Rintatolimod wikiPageID "7906898".
- Rintatolimod wikiPageRevisionID "592941282".
- Rintatolimod atcPrefix "none".
- Rintatolimod casNumber "38640".
- Rintatolimod chemspiderid "34908".
- Rintatolimod hasPhotoCollection Rintatolimod.
- Rintatolimod inchi "1".
- Rintatolimod inchikey "KNUXHTWUIVMBBY-JRJYXWDABE".
- Rintatolimod iupacName "5".
- Rintatolimod niaidChemdb "136".
- Rintatolimod routesOfAdministration "IV".
- Rintatolimod smiles "O=POC[C@H]3O[C@@H][C@H][C@@H]3O.O=C1/N=C\C=C/N1[C@@H]2O[C@H][C@@H][C@H]2O.O=C/1NCN[C@@H]2O[C@@H]COPO".
- Rintatolimod stdinchi "1".
- Rintatolimod stdinchikey "KNUXHTWUIVMBBY-JRJYXWDASA-N".
- Rintatolimod synonyms "PolyI:PolyC12U".
- Rintatolimod tradename "Ampligen".
- Rintatolimod unii "94325".
- Rintatolimod verifiedrevid "420793656".
- Rintatolimod width "200".
- Rintatolimod subject Category:Anti-RNA_virus_drugs.
- Rintatolimod subject Category:Immunostimulants.
- Rintatolimod type Agent114778436.
- Rintatolimod type Antiviral102725367.
- Rintatolimod type Antivirals.
- Rintatolimod type CausalAgent100007347.
- Rintatolimod type Drug103247620.
- Rintatolimod type Matter100020827.
- Rintatolimod type Medicine103740161.
- Rintatolimod type PhysicalEntity100001930.
- Rintatolimod type Substance100020090.
- Rintatolimod type Drug.
- Rintatolimod type FunctionalSubstance.
- Rintatolimod comment "Rintatolimod (tradename Ampligen, also known as poly I:poly C12U), is an experimental immunomodulatory double stranded RNA drug developed by Hemispherx Biopharma of Philadelphia, Pennsylvania.".
- Rintatolimod label "Rintatolimod".
- Rintatolimod sameAs m.026jl_1.
- Rintatolimod sameAs Q7335107.
- Rintatolimod sameAs Q7335107.
- Rintatolimod sameAs Rintatolimod.
- Rintatolimod wasDerivedFrom Rintatolimod?oldid=592941282.
- Rintatolimod isPrimaryTopicOf Rintatolimod.