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- Robinson_annulation abstract "The Robinson annulation is a chemical reaction used in organic chemistry for ring formation. It was discovered by Robert Robinson in 1935 as a method to create a six membered ring by forming three new carbon–carbon bonds. The method uses a ketone and a methyl vinyl ketone to form an α,β-unsaturated ketone in a cyclohexane ring by a Michael addition followed by an aldol condensation. This procedure is one of the key methods to form fused ring systems. Formation of cyclohexenone and derivatives are important in chemistry for their application to the synthesis of many natural products and other interesting organic compounds such as antibiotics and steroids. Specifically, the synthesis of cortisone is completed through the use of the Robinson annulation.The initial paper on the Robinson annulation was published by William Rapson and Robert Robinson while Rapson studied at Oxford with Professor Robinson. Prior to their work, cyclohexenone syntheses were not derived from the α,β-unsaturated ketone component. Initial approaches coupled the methyl vinyl ketone with a naphthol to give a naphtholoxide, but this procedure was not sufficient to form the desired cyclohexenone. This was attributed to unsuitable conditions of the reaction.Robinson and Rapson found in 1935 that the interaction between cyclohexanone and α,β-unsaturated ketone afforded the desired cyclohexenone. It remains one of the key methods for the construction of six membered ring compounds. Since it is so widely used, there are many aspects of the reaction that have been investigated such as variations of the substrates and reaction conditions as discussed in the scope and variations section. Robert Robinson won the Nobel Prize for Chemistry in 1947 for his contribution to the study of alkaloids.".
- Robinson_annulation thumbnail Reaction_Scheme_for_Robinson_Annulation.svg?width=300.
- Robinson_annulation wikiPageID "1653141".
- Robinson_annulation wikiPageRevisionID "600723088".
- Robinson_annulation hasPhotoCollection Robinson_annulation.
- Robinson_annulation subject Category:Addition_reactions.
- Robinson_annulation subject Category:Carbon-carbon_bond_forming_reactions.
- Robinson_annulation subject Category:Name_reactions.
- Robinson_annulation type AdditionReaction113427356.
- Robinson_annulation type AdditionReactions.
- Robinson_annulation type ChemicalProcess113446390.
- Robinson_annulation type ChemicalReaction113447361.
- Robinson_annulation type NameReactions.
- Robinson_annulation type NaturalProcess113518963.
- Robinson_annulation type PhysicalEntity100001930.
- Robinson_annulation type Process100029677.
- Robinson_annulation comment "The Robinson annulation is a chemical reaction used in organic chemistry for ring formation. It was discovered by Robert Robinson in 1935 as a method to create a six membered ring by forming three new carbon–carbon bonds. The method uses a ketone and a methyl vinyl ketone to form an α,β-unsaturated ketone in a cyclohexane ring by a Michael addition followed by an aldol condensation. This procedure is one of the key methods to form fused ring systems.".
- Robinson_annulation label "Anelación de Robinson".
- Robinson_annulation label "Anellazione di Robinson".
- Robinson_annulation label "Annélation de Robinson".
- Robinson_annulation label "Robinson annulation".
- Robinson_annulation label "Robinson-Anellierung".
- Robinson_annulation label "Robinson-annulering".
- Robinson_annulation label "ロビンソン環化反応".
- Robinson_annulation label "罗宾逊成环反应".
- Robinson_annulation sameAs Robinson-Anellierung.
- Robinson_annulation sameAs Anelación_de_Robinson.
- Robinson_annulation sameAs Annélation_de_Robinson.
- Robinson_annulation sameAs Anellazione_di_Robinson.
- Robinson_annulation sameAs ロビンソン環化反応.
- Robinson_annulation sameAs Robinson-annulering.
- Robinson_annulation sameAs m.05kwyl.
- Robinson_annulation sameAs Q531398.
- Robinson_annulation sameAs Q531398.
- Robinson_annulation sameAs Robinson_annulation.
- Robinson_annulation wasDerivedFrom Robinson_annulation?oldid=600723088.
- Robinson_annulation depiction Reaction_Scheme_for_Robinson_Annulation.svg.
- Robinson_annulation isPrimaryTopicOf Robinson_annulation.
