Data Portal @ linkeddatafragments.org

Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Rosiglitazone> ?p ?o. }

• Rosiglitazone abstract "Rosiglitazone (trade name Avandia, GlaxoSmithKline) is an antidiabetic drug in the thiazolidinedione class of drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride. First released in 1999, annual sales peaked at approximately $2.5-billion in 2006; however, following a meta-analysis published in the New England Journal of Medicine in 2007 that linked the drug's use to an increased risk of heart attack, sales plummeted to just $9.5-million in 2012. The drug's patent expired in 2012.Despite rosiglitazone's effectiveness at decreasing blood sugar in type 2 diabetes mellitus, its use decreased dramatically as studies showed apparent associations with increased risks of heart attacks and death. Adverse effects alleged to be caused by rosiglitazone were the subject of over 13,000 lawsuits against GSK; as of July 2010, GSK had agreed to settlements on more than 11,500 of these suits.Some reviewers recommended rosiglitazone be taken off the market, but an FDA panel disagreed, and it remains available in the U.S. From November 2011 until November 2013, the federal government did not allow Avandia to be sold without a prescription from a certified doctor; moreover, patients were required to be informed of the risks associated with its use, and the drug had to be purchased by mail order through specified pharmacies. In November 2013, the FDA lifted its earlier restrictions on rosiglitazone after reviewing the results of the 2009 RECORD clinical trial (a six-year, open label randomized control trial), which failed to show the heart infarct risks associated with the drug.In Europe, the European Medicines Agency (EMA) recommended in September 2010 that the drug be suspended from the European market because the benefits of rosiglitazone no longer outweighed the risks. It was withdrawn from the market in the UK and India in 2010, and in New Zealand and South Africa in 2011.".
• Rosiglitazone atcPrefix "A10".
• Rosiglitazone atcSuffix "BG02".
• Rosiglitazone bioavailability "99.0".
• Rosiglitazone casNumber "122320-73-4".
• Rosiglitazone chEBI "50122".
• Rosiglitazone drugbank "DB00412".
• Rosiglitazone fdaUniiCode "05V02F2KDG".
• Rosiglitazone iupacName "(RS)-5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione".
• Rosiglitazone pubchem "77999".
• Rosiglitazone thumbnail Rosiglitazone.svg?width=300.
• Rosiglitazone wikiPageExternalLink dpdirect.jsp?name=Rosiglitazone.
• Rosiglitazone wikiPageExternalLink www.avandia.com.
• Rosiglitazone wikiPageExternalLink ?ligand=BRL.
• Rosiglitazone wikiPageExternalLink ?ligand=RGZ.
• Rosiglitazone wikiPageExternalLink 483837.
• Rosiglitazone wikiPageExternalLink a699023.html.
• Rosiglitazone wikiPageID "604046".
• Rosiglitazone wikiPageRevisionID "606791806".
• Rosiglitazone atcPrefix "A10".
• Rosiglitazone atcSuffix "BG02".
• Rosiglitazone bioavailability "99.0".
• Rosiglitazone c "18".
• Rosiglitazone casNumber "122320".
• Rosiglitazone chebi "50122".
• Rosiglitazone chembl "121".
• Rosiglitazone chemspiderid "70383".
• Rosiglitazone drugName "Rosiglitazone".
• Rosiglitazone drugbank "DB00412".
• Rosiglitazone eliminationHalfLife "-14400.0".
• Rosiglitazone excretion "Renal and fecal".
• Rosiglitazone h "19".
• Rosiglitazone hasPhotoCollection Rosiglitazone.
• Rosiglitazone image "Rosiglitazone ball-and-stick.png".
• Rosiglitazone imagename "1".
• Rosiglitazone inchi "1".
• Rosiglitazone inchikey "YASAKCUCGLMORW-UHFFFAOYAR".
• Rosiglitazone iupacName "-5".
• Rosiglitazone iupharLigand "1056".
• Rosiglitazone kegg "D00596".
• Rosiglitazone legalUk "POM".
• Rosiglitazone legalUs "Rx-only".
• Rosiglitazone licenceEu "Avandia".
• Rosiglitazone licenceUs "Rosiglitazone".
• Rosiglitazone medlineplus "a699023".
• Rosiglitazone metabolism "Hepatic".
• Rosiglitazone molecularWeight "357.428".
• Rosiglitazone n "3".
• Rosiglitazone o "3".
• Rosiglitazone pdbLigand "RGZ".
• Rosiglitazone pregnancyAu "B3".
• Rosiglitazone pregnancyUs "C".
• Rosiglitazone proteinBound "99.8".
• Rosiglitazone pubchem "77999".
• Rosiglitazone routesOfAdministration "Oral".
• Rosiglitazone s "1".
• Rosiglitazone smiles "O=C1NCSC1Cc3ccccc3".
• Rosiglitazone stdinchi "1".
• Rosiglitazone stdinchikey "YASAKCUCGLMORW-UHFFFAOYSA-N".
• Rosiglitazone tradename "Avandia".
• Rosiglitazone unii "5".
• Rosiglitazone verifiedfields "changed".
• Rosiglitazone verifiedrevid "458777178".
• Rosiglitazone width "200".
• Rosiglitazone subject Category:Phenol_ethers.
• Rosiglitazone subject Category:Pyridines.
• Rosiglitazone subject Category:Thiazolidinediones.
• Rosiglitazone subject Category:Withdrawn_drugs.
• Rosiglitazone type Abstraction100002137.
• Rosiglitazone type Base114618253.
• Rosiglitazone type Chemical114806838.
• Rosiglitazone type Compound114818238.
• Rosiglitazone type Element114840755.
• Rosiglitazone type Material114580897.
• Rosiglitazone type Matter100020827.
• Rosiglitazone type Part113809207.
• Rosiglitazone type PhenolEthers.
• Rosiglitazone type PhysicalEntity100001930.
• Rosiglitazone type Pyridine114692510.
• Rosiglitazone type Pyridines.
• Rosiglitazone type Quintessence114847103.
• Rosiglitazone type Relation100031921.
• Rosiglitazone type Substance100019613.
• Rosiglitazone type Drug.
• Rosiglitazone type DrugProduct.
• Rosiglitazone type FunctionalSubstance.
• Rosiglitazone comment "Rosiglitazone (trade name Avandia, GlaxoSmithKline) is an antidiabetic drug in the thiazolidinedione class of drugs. It works as an insulin sensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.".
• Rosiglitazone label "Rosiglitazon".
• Rosiglitazone label "Rosiglitazona".
• Rosiglitazone label "Rosiglitazone".
• Rosiglitazone label "Rosiglitazone".
• Rosiglitazone label "Rozyglitazon".
• Rosiglitazone label "Росиглитазон".
• Rosiglitazone label "罗格列酮".
• Rosiglitazone sameAs Rosiglitazon.
• Rosiglitazone sameAs Rosiglitazone.
• Rosiglitazone sameAs Rozyglitazon.
• Rosiglitazone sameAs Rosiglitazona.
• Rosiglitazone sameAs m.02vn54.
• Rosiglitazone sameAs Q424771.

• next