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- Rotavirus_translation abstract "Rotavirus translation, the process of translating mRNA into proteins, occurs in a different way in Rotaviruses. Unlike the vast majority of cellular proteins in other organisms, in Rotaviruses the proteins are translated from capped but nonpolyadenylated mRNAs. The viral nonstructural protein NSP3 specifically binds the 3'-end consensus sequence of viral mRNAs and interacts with the eukaryotic translation initiation factor eIF4G. The Rotavirus replication cycle occurs entirely in the cytoplasm. Upon virus entry, the viral transcriptase synthesizes capped but nonpolyadenylated mRNA The viral mRNAs bear 5' and 3' untranslated regions (UTR) of variable length and are flanked by two different sequences common to all genes.In the group A rotaviruses, the 3'-end consensus sequence UGACC is highly conserved among the 11 genes. Rotavirus NSP3 presents several similarities to PABP; in rotavirus-infected cells, NSP3 can be cross-linked to the 3' end of rotavirus mRNAs and is coimmunoprecipitated with eIF4G. The binding of NSP3A to eIF4G and its specific interaction with the 3' end of viral mRNA brings the viral mRNA and the translation initiation machinery into contact, thus favoring efficient translation of the viral mRNA. NSP3 interacts with the same region of eIF4G as PABP does. As a consequence, during rotavirus infection PABP is evicted from eIF4G, probably impairing the translation of polyadenylated mRNA and leading to the shutoff of cellular mRNA translation observed during rotavirus infection.Cellular versus Rotaviral Translation.".
- Rotavirus_translation thumbnail Rotavirus_Translation.svg?width=300.
- Rotavirus_translation wikiPageID "13958600".
- Rotavirus_translation wikiPageRevisionID "561068552".
- Rotavirus_translation hasPhotoCollection Rotavirus_translation.
- Rotavirus_translation subject Category:Gene_expression.
- Rotavirus_translation subject Category:Molecular_biology.
- Rotavirus_translation subject Category:Protein_biosynthesis.
- Rotavirus_translation subject Category:Rotaviruses.
- Rotavirus_translation type Agent109190918.
- Rotavirus_translation type AnimalVirus101335659.
- Rotavirus_translation type CausalAgent100007347.
- Rotavirus_translation type InfectiousAgent109312843.
- Rotavirus_translation type LivingThing100004258.
- Rotavirus_translation type Microorganism101326291.
- Rotavirus_translation type Object100002684.
- Rotavirus_translation type Organism100004475.
- Rotavirus_translation type PhysicalEntity100001930.
- Rotavirus_translation type Reovirus101340935.
- Rotavirus_translation type Rotavirus101341090.
- Rotavirus_translation type Rotaviruses.
- Rotavirus_translation type Virus101328702.
- Rotavirus_translation type Viruses.
- Rotavirus_translation type Whole100003553.
- Rotavirus_translation comment "Rotavirus translation, the process of translating mRNA into proteins, occurs in a different way in Rotaviruses. Unlike the vast majority of cellular proteins in other organisms, in Rotaviruses the proteins are translated from capped but nonpolyadenylated mRNAs. The viral nonstructural protein NSP3 specifically binds the 3'-end consensus sequence of viral mRNAs and interacts with the eukaryotic translation initiation factor eIF4G.".
- Rotavirus_translation label "Rotavirus translation".
- Rotavirus_translation sameAs m.03cpf9y.
- Rotavirus_translation sameAs Q7370336.
- Rotavirus_translation sameAs Q7370336.
- Rotavirus_translation sameAs Rotavirus_translation.
- Rotavirus_translation wasDerivedFrom Rotavirus_translation?oldid=561068552.
- Rotavirus_translation depiction Rotavirus_Translation.svg.
- Rotavirus_translation isPrimaryTopicOf Rotavirus_translation.
