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- RyhB_RNA abstract "RyhB RNA is a 90 nucleotide non-coding RNA that down-regulates a set of iron-storage and iron-using proteins when iron is limiting; it is itself negatively regulated by the ferric uptake repressor protein, Fur (Ferric uptake regulator). This ncRNA gene was independently identified in two screens, named RyhB by Wasserman et al. and called SraI by Argaman et al. and was found to be expressed only in stationary phase. RyhB RNA levels are inversely correlated with mRNA levels for the sdhCDAB operon, encoding succinate dehydrogenase, as well as five other genes previously shown to be positively regulated by Fur by an unknown mechanism. These include two other genes encoding enzymes in the tricarboxylic acid cycle, acnA and fumA, two ferritin genes, ftnA and bfr, and a gene for superoxide dismutase, sodB. A number of other genes have been predicted computationally and verified as targets by microarray analysis: napF, sodA, cysE, yciS, acpS, nagZ and dadA. RyhB is bound by the Hfq protein, that increases its interaction with its target messages.A comparative genomics target prediction approach suggests that the mRNAs of eleven additional iron containing proteins are controlled by RyhB in Escherichia coli. Two of those (erpA, nirB) and two additional targets that are not directly related to iron (nagZ, marA) were verified with a GFP reporter system.It has been shown that RyhB has a role in targeting the polycistronic transcript iscRSUA for differential degradation. RyhB binds to the second cistron of iscRSUA, which encodes machinery for biosynthesis of Fe-S clusters. This binding promotes cleavage of the downstream iscSUA transcript. This cleavage leaves the 5' IscR transcript which is a transcriptional regulator responsible regulating several genes that depend on cellular Fe-S level.RyhB is an analog of the sRNA PrrF RNA found in Pseudomonas aeruginosa.".
- RyhB_RNA thumbnail RyhB_sodB.jpg?width=300.
- RyhB_RNA wikiPageID "11421489".
- RyhB_RNA wikiPageRevisionID "592967327".
- RyhB_RNA hasPhotoCollection RyhB_RNA.
- RyhB_RNA id "RF00057".
- RyhB_RNA name "RyhB RNA".
- RyhB_RNA subject Category:Non-coding_RNA.
- RyhB_RNA comment "RyhB RNA is a 90 nucleotide non-coding RNA that down-regulates a set of iron-storage and iron-using proteins when iron is limiting; it is itself negatively regulated by the ferric uptake repressor protein, Fur (Ferric uptake regulator). This ncRNA gene was independently identified in two screens, named RyhB by Wasserman et al. and called SraI by Argaman et al. and was found to be expressed only in stationary phase.".
- RyhB_RNA label "RyhB RNA".
- RyhB_RNA sameAs m.02rb_dd.
- RyhB_RNA sameAs Q7385058.
- RyhB_RNA sameAs Q7385058.
- RyhB_RNA wasDerivedFrom RyhB_RNA?oldid=592967327.
- RyhB_RNA depiction RyhB_sodB.jpg.
- RyhB_RNA isPrimaryTopicOf RyhB_RNA.
