Matches in DBpedia 2014 for { <http://dbpedia.org/resource/S32212> ?p ?o. }
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- S32212 abstract "S32212 is a drug which is under preclinical investigation as a potential antidepressant medicine. It behaves as a selective, combined 5-HT2C receptor inverse agonist and α2-adrenergic receptor antagonist (at all three subtypes—α2A, α2B, and α2C) with additional 5-HT2A and, to a lesser extent, 5-HT2B receptor antagonistic properties, and lacks any apparent affinity for the monoamine reuptake transporters or for the α1-adrenergic, H1, or mACh receptors. This profile of activity is compatible with the definition of a noradrenergic and specific serotonergic antidepressant (NaSSA), and as such, S32212 could in turn be classified as a NaSSA if it reaches the market.In animal studies, S32212 raised BDNF concentrations in the hippocampus and amygdala, increased the firing rate of neurons in the adrenergic perikarya in the locus coeruleus, increased levels of norepinephrine in the frontal cortex and hippocampus, and elevated frontal cortex levels of dopamine and acetylcholine, though not of serotonin or histamine. It produces effects indicative of antidepressant, anxiolytic, antiobsessional, antiaggressive, and cognitive- and sleep-enhancing properties in animal models, all while not perturbing body weight or sexual behavior.".
- S32212 atcPrefix "None".
- S32212 iupacName "N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-1,2-dihydro-3H-benzo[e]indole-3-carboxamide".
- S32212 pubchem "11384503".
- S32212 thumbnail S32212.svg?width=300.
- S32212 wikiPageID "35599329".
- S32212 wikiPageRevisionID "592968962".
- S32212 atcPrefix "None".
- S32212 c "25".
- S32212 chemspiderid "9559416".
- S32212 h "28".
- S32212 hasPhotoCollection S32212.
- S32212 inchi "1".
- S32212 inchikey "HNWBOBAUHUFDES-UHFFFAOYAA".
- S32212 iupacName "N-[4-methoxy-3-phenyl]-1,2-dihydro-3H-benzo[e]indole-3-carboxamide".
- S32212 molecularWeight "416.515".
- S32212 n "4".
- S32212 o "2".
- S32212 pubchem "11384503".
- S32212 smiles "O=CNc4ccN5CCNCC5".
- S32212 stdinchi "1".
- S32212 stdinchikey "HNWBOBAUHUFDES-UHFFFAOYSA-N".
- S32212 subject Category:Alpha-2_blockers.
- S32212 subject Category:Carboxamides.
- S32212 subject Category:Indoles.
- S32212 subject Category:Noradrenergic_and_specific_serotonergic_antidepressants.
- S32212 subject Category:Piperazines.
- S32212 subject Category:Serotonin_antagonists.
- S32212 type Drug.
- S32212 type FunctionalSubstance.
- S32212 comment "S32212 is a drug which is under preclinical investigation as a potential antidepressant medicine. It behaves as a selective, combined 5-HT2C receptor inverse agonist and α2-adrenergic receptor antagonist (at all three subtypes—α2A, α2B, and α2C) with additional 5-HT2A and, to a lesser extent, 5-HT2B receptor antagonistic properties, and lacks any apparent affinity for the monoamine reuptake transporters or for the α1-adrenergic, H1, or mACh receptors.".
- S32212 label "S32212".
- S32212 sameAs m.0jl1tgb.
- S32212 sameAs Q7388266.
- S32212 sameAs Q7388266.
- S32212 wasDerivedFrom S32212?oldid=592968962.
- S32212 depiction S32212.svg.
- S32212 isPrimaryTopicOf S32212.
