Matches in DBpedia 2014 for { <http://dbpedia.org/resource/SAFB> ?p ?o. }
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- SAFB abstract "Scaffold attachment factor B, also known as SAFB, is a gene with homologs that have been studied in humans and mice.This gene encodes a DNA-binding protein that has specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there are conflicting views as to whether this protein is a component of chromatin, the nuclear matrix, or both. Scaffold attachment factors are a subset of nuclear matrix proteins (NMP) with enriched binding to AT-rich S/MAR sequences. The SAF-B protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.".
- SAFB entrezgene "6294".
- SAFB wikiPageID "14756592".
- SAFB wikiPageRevisionID "592972907".
- SAFB hasPhotoCollection SAFB.
- SAFB requireManualInspection "no".
- SAFB summaryText "This gene encodes a DNA-binding protein that has specificity for scaffold or matrix attachment region DNA elements . This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there are conflicting views as to whether this protein is a component of chromatin, the nuclear matrix, or both. Scaffold attachment factors are a subset of nuclear matrix proteins with enriched binding to AT-rich S/MAR sequences. The SAF-B protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.".
- SAFB updateCitations "yes".
- SAFB updatePage "yes".
- SAFB updateProteinBox "yes".
- SAFB updateSummary "yes".
- SAFB type Biomolecule.
- SAFB type Protein.
- SAFB type BiologicalObject.
- SAFB comment "Scaffold attachment factor B, also known as SAFB, is a gene with homologs that have been studied in humans and mice.This gene encodes a DNA-binding protein that has specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there are conflicting views as to whether this protein is a component of chromatin, the nuclear matrix, or both.".
- SAFB label "SAFB".
- SAFB sameAs m.03gww1t.
- SAFB sameAs Q7388518.
- SAFB sameAs Q7388518.
- SAFB wasDerivedFrom SAFB?oldid=592972907.
- SAFB isPrimaryTopicOf SAFB.