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- SB-271,046 abstract "SB-271,046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271,046 through a structure-activity relationship (SAR) study. SB-271,046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood–brain barrier, so further SAR work was then conducted, which led to improved 5-HT6 antagonists such as SB-357,134 and SB-399,885.SB-271,046 was found to increase levels of the excitatory amino acid neurotransmitters glutamate and aspartate, as well as dopamine and noradrenaline in the frontal cortex and hippocampus of rats, and 5-HT6 antagonists have been shown to produce nootropic effects in a variety of animal studies. Suggested applications of these drugs include treatment of schizophrenia and other psychiatric disorders.".
- SB-271,046 iupacName "5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide".
- SB-271,046 pubchem "5312149".
- SB-271,046 thumbnail SB-271,046_structure.png?width=300.
- SB-271,046 wikiPageID "19999911".
- SB-271,046 wikiPageRevisionID "600915261".
- SB-271,046 c "20".
- SB-271,046 chembl "431298".
- SB-271,046 cl "1".
- SB-271,046 h "22".
- SB-271,046 hasPhotoCollection SB-271,046.
- SB-271,046 iupacName "5".
- SB-271,046 iupharLigand "276".
- SB-271,046 molecularWeight "451.989".
- SB-271,046 n "3".
- SB-271,046 o "3".
- SB-271,046 pubchem "5312149".
- SB-271,046 s "2".
- SB-271,046 smiles "C4CNCCN4c3ccNSc1sc2ccccc2c1C".
- SB-271,046 verifiedfields "changed".
- SB-271,046 verifiedrevid "407719655".
- SB-271,046 width "240".
- SB-271,046 subject Category:5-HT6_antagonists.
- SB-271,046 subject Category:Benzothiophenes.
- SB-271,046 subject Category:Organochlorides.
- SB-271,046 subject Category:Phenol_ethers.
- SB-271,046 subject Category:Piperazines.
- SB-271,046 subject Category:Sulfonamides.
- SB-271,046 type Drug.
- SB-271,046 type DrugProduct.
- SB-271,046 type FunctionalSubstance.
- SB-271,046 comment "SB-271,046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271,046 through a structure-activity relationship (SAR) study.".
- SB-271,046 label "SB-271,046".
- SB-271,046 label "SB-271,046".
- SB-271,046 sameAs SB-271,046.
- SB-271,046 sameAs m.04y9kf9.
- SB-271,046 sameAs Q855568.
- SB-271,046 sameAs Q855568.
- SB-271,046 wasDerivedFrom SB-271,046?oldid=600915261.
- SB-271,046 depiction SB-271,046_structure.png.
- SB-271,046 isPrimaryTopicOf SB-271,046.
