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- SENP6 abstract "Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000).[supplied by OMIM]".
- SENP6 entrezgene "26054".
- SENP6 wikiPageID "14877396".
- SENP6 wikiPageRevisionID "601785664".
- SENP6 hasPhotoCollection SENP6.
- SENP6 requireManualInspection "no".
- SENP6 summaryText "Ubiquitin-like molecules , such as SUMO1 , are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins .[supplied by OMIM]".
- SENP6 updateCitations "yes".
- SENP6 updatePage "yes".
- SENP6 updateProteinBox "yes".
- SENP6 updateSummary "yes".
- SENP6 type Biomolecule.
- SENP6 type Protein.
- SENP6 type BiologicalObject.
- SENP6 comment "Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins.".
- SENP6 label "SENP6".
- SENP6 sameAs m.03g_zh7.
- SENP6 sameAs Q7389742.
- SENP6 sameAs Q7389742.
- SENP6 wasDerivedFrom SENP6?oldid=601785664.
- SENP6 isPrimaryTopicOf SENP6.