Matches in DBpedia 2014 for { <http://dbpedia.org/resource/SGK> ?p ?o. }
Showing items 1 to 26 of
26
with 100 items per page.
- SGK abstract "Serine/threonine-protein kinase SGK is a kinase subfamily that is known as being encoded by SGK1, SGK2, and SGK3 genes.Among the three SGK genes, the SGL1 gene is the most intensively studied. This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta), which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, an involvement of SGK in the development of this condition is suggested.The SGK1 kinase regulates the myo-inositol transporter during osmotic stress.Deregulated expression of SGK1 in the endometrium has been implicated in cases of infertility or recurrent miscarriage in humans, and SGK1 expression in the endometrium also affects fertility in mice.".
- SGK entrezgene "6446".
- SGK wikiPageExternalLink 6446.
- SGK wikiPageID "14118531".
- SGK wikiPageRevisionID "602146132".
- SGK hasPhotoCollection SGK.
- SGK requireManualInspection "no".
- SGK summaryText "Among the three SGK genes, the SGL1 gene is the most intensively studied. This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase . This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta , which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, an involvement of SGK in the development of this condition is suggested.".
- SGK updateCitations "yes".
- SGK updatePage "yes".
- SGK updateProteinBox "yes".
- SGK updateSummary "yes".
- SGK type Biomolecule.
- SGK type Protein.
- SGK type BiologicalObject.
- SGK comment "Serine/threonine-protein kinase SGK is a kinase subfamily that is known as being encoded by SGK1, SGK2, and SGK3 genes.Among the three SGK genes, the SGL1 gene is the most intensively studied. This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling.".
- SGK label "SGK".
- SGK label "SGK1".
- SGK label "Serina/treonina protein-chinasi SGK".
- SGK sameAs SGK1.
- SGK sameAs treonina_protein-chinasi_SGK.
- SGK sameAs m.03cv560.
- SGK sameAs Q3459529.
- SGK sameAs Q3459529.
- SGK wasDerivedFrom SGK?oldid=602146132.
- SGK isPrimaryTopicOf SGK.