Matches in DBpedia 2014 for { <http://dbpedia.org/resource/SKAP1> ?p ?o. }
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- SKAP1 abstract "Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.The demonstration that SKAP1 regulates LFA-1 adhesion was made by retroviral infection and by the SKAP1 deficient mouse. Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.".
- SKAP1 entrezgene "8631".
- SKAP1 wikiPageID "14819484".
- SKAP1 wikiPageRevisionID "593056895".
- SKAP1 hasPhotoCollection SKAP1.
- SKAP1 requireManualInspection "no".
- SKAP1 summaryText "This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adapter protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.".
- SKAP1 updateCitations "yes".
- SKAP1 updatePage "yes".
- SKAP1 updateProteinBox "yes".
- SKAP1 updateSummary "yes".
- SKAP1 type Biomolecule.
- SKAP1 type Protein.
- SKAP1 type BiologicalObject.
- SKAP1 comment "Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.This gene encodes a T cell adapter protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain.".
- SKAP1 label "SKAP1".
- SKAP1 sameAs m.03gz1sd.
- SKAP1 sameAs Q7390584.
- SKAP1 sameAs Q7390584.
- SKAP1 wasDerivedFrom SKAP1?oldid=593056895.
- SKAP1 isPrimaryTopicOf SKAP1.