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- SLUDGE_syndrome abstract "SLUDGE is a mnemonic for the pathological effects indicative of massive discharge of the parasympathetic nervous system. Unlikely to occur naturally, SLUDGE is usually encountered only in cases of drug overdose, ingestion of certain poisonous mushrooms (particularly the muscarine-containing members of the genera Inocybe and Clitocybe), or exposure to nerve gases. The symptoms of "SLUDGE" are due to chronic stimulation of muscarinic acetylcholine receptors, in organs and muscles innervated by the parasympathetic nervous system. It is useful to remember some of the symptoms of increased cholinergic stimulation through the mnemonic SLUDGE: Salivation: stimulation of the salivary glands Lacrimation: stimulation of the lacrimal glands Urination: relaxation of the internal sphincter muscle of urethra, and contraction of the detrusor muscles Defecation: relaxation of the internal anal sphincter Gastrointestinal upset: Smooth muscle tone changes causing gastrointestinal problems, including diarrhea Emesis:VomitingAn extension is SLUDGEM, where the additional M indicates:Miosis:stimulation of the pupillary constrictor musclesorMuscle spasm:stimulation of skeletal muscleOne common cause of SLUDGE is exposure to organophosphorus insecticides (including parathion, malathion, and diazinon) or nerve gas, such as sarin. These agents phosphorylate acetylcholinesterase, thereby irreversibly deactivating acetylcholinesterase and raising acetylcholine levels and causing SLUDGE(M).SLUDGE may be treated with atropine, pralidoxime or other anticholinergics.".
- SLUDGE_syndrome wikiPageID "7290898".
- SLUDGE_syndrome wikiPageRevisionID "577247766".
- SLUDGE_syndrome hasPhotoCollection SLUDGE_syndrome.
- SLUDGE_syndrome subject Category:Nerve_agents.
- SLUDGE_syndrome subject Category:Symptoms.
- SLUDGE_syndrome subject Category:Toxic_effects_of_pesticides.
- SLUDGE_syndrome type Agent114778436.
- SLUDGE_syndrome type Artifact100021939.
- SLUDGE_syndrome type CausalAgent100007347.
- SLUDGE_syndrome type ChemicalWeapon103013162.
- SLUDGE_syndrome type Device103183080.
- SLUDGE_syndrome type Fluid114939445.
- SLUDGE_syndrome type Gas114877585.
- SLUDGE_syndrome type Instrument103574816.
- SLUDGE_syndrome type Instrumentality103575240.
- SLUDGE_syndrome type Matter100020827.
- SLUDGE_syndrome type NerveAgents.
- SLUDGE_syndrome type NerveGas114960721.
- SLUDGE_syndrome type Object100002684.
- SLUDGE_syndrome type PhysicalEntity100001930.
- SLUDGE_syndrome type PoisonGas114993378.
- SLUDGE_syndrome type Substance100020090.
- SLUDGE_syndrome type Weapon104565375.
- SLUDGE_syndrome type WeaponOfMassDestruction104565963.
- SLUDGE_syndrome type Whole100003553.
- SLUDGE_syndrome comment "SLUDGE is a mnemonic for the pathological effects indicative of massive discharge of the parasympathetic nervous system. Unlikely to occur naturally, SLUDGE is usually encountered only in cases of drug overdose, ingestion of certain poisonous mushrooms (particularly the muscarine-containing members of the genera Inocybe and Clitocybe), or exposure to nerve gases.".
- SLUDGE_syndrome label "SLUDGE syndrome".
- SLUDGE_syndrome sameAs m.025yc7f.
- SLUDGE_syndrome sameAs Q7391005.
- SLUDGE_syndrome sameAs Q7391005.
- SLUDGE_syndrome sameAs SLUDGE_syndrome.
- SLUDGE_syndrome wasDerivedFrom SLUDGE_syndrome?oldid=577247766.
- SLUDGE_syndrome isPrimaryTopicOf SLUDGE_syndrome.