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- SNi abstract "SNi or Substitution Nucleophilic internal stands for a specific but not often encountered nucleophilic aliphatic substitution reaction mechanism. The name was introduced by Cowdrey et al. in 1937 to label nucleophilic reactions which occur with retention of configuration, but later was employed to describe various reactions that proceed with similar mechanism. A typical representative organic reaction displaying this mechanism is the chlorination of alcohols with thionyl chloride, or the decomposition of alkyl chloroformates, the main feature is retention of stereochemical configuration. Some examples for this reaction were reported by Edward S. Lewis and Charles E. Boozer in 1952. Mechanistic and kinetic studies were reported few years later by various researchers. Thionyl chloride first reacts with the alcohol to form an alkyl chloro sulfite, actually forming an intimate ion pair. The second step is the concerted loss of a sulfur dioxide molecule and its replacement by the chloride, which was attached to the sulfite group. The difference between SN1 and SNi is actually that the ion pair is not completely dissociated, and therefore no real carbocation is formed, which else would lead to a racemisation. This reaction type is linked to many forms of neighbouring group participation, for instance the reaction of the sulfur or nitrogen lone pair in sulfur mustard or nitrogen mustard to form the cationic intermediate.This reaction mechanism is supported by the observation that addition of pyridine to the reaction leads to inversion. The reasoning behind this finding is that pyridine reacts with the intermediate sulfite replacing chlorine. The dislodged chlorine has to resort to nucleophilic attack from the rear as in a regular nucleophilic substitution.In the complete picture for this reaction the sulfite reacts with a chlorine ion in a standard SN2 reaction with inversion of configuration. When the solvent is also a nucleophile such as dioxane two successive SN2 reactions take place and the stereochemistry is again retention. With standard SN1 reaction conditions the reaction outcome is retention via a competing SNi mechanism and not racemization and with pyridine added the result is again inversion.".
- SNi thumbnail SNi_reaction_mechanism.gif?width=300.
- SNi wikiPageID "2726466".
- SNi wikiPageRevisionID "583670183".
- SNi hasPhotoCollection SNi.
- SNi subject Category:Reaction_mechanisms.
- SNi subject Category:Substitution_reactions.
- SNi type ChemicalProcess113446390.
- SNi type ChemicalReaction113447361.
- SNi type Mechanism113512506.
- SNi type NaturalProcess113518963.
- SNi type PhysicalEntity100001930.
- SNi type Process100029677.
- SNi type ReactionMechanisms.
- SNi type SubstitutionReactions.
- SNi comment "SNi or Substitution Nucleophilic internal stands for a specific but not often encountered nucleophilic aliphatic substitution reaction mechanism. The name was introduced by Cowdrey et al. in 1937 to label nucleophilic reactions which occur with retention of configuration, but later was employed to describe various reactions that proceed with similar mechanism.".
- SNi label "Interne nucleofiele substitutie".
- SNi label "SNi".
- SNi label "分子内亲核取代反应".
- SNi sameAs Interne_nucleofiele_substitutie.
- SNi sameAs m.07_7sg.
- SNi sameAs Q1092165.
- SNi sameAs Q1092165.
- SNi sameAs SNi.
- SNi wasDerivedFrom SNi?oldid=583670183.
- SNi depiction SNi_reaction_mechanism.gif.
- SNi isPrimaryTopicOf SNi.
