Matches in DBpedia 2014 for { <http://dbpedia.org/resource/SOCS3> ?p ?o. }
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- SOCS3 abstract "Suppressor of cytokine signaling 3 is a protein that in humans is encoded by the SOCS3 gene.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be cruicial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.".
- SOCS3 entrezgene "9021".
- SOCS3 wikiPageID "14112356".
- SOCS3 wikiPageRevisionID "593068814".
- SOCS3 hasPhotoCollection SOCS3.
- SOCS3 requireManualInspection "no".
- SOCS3 summaryText "This gene encodes a member of the STAT-induced STAT inhibitor , also known as suppressor of cytokine signaling , family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon -gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be cruicial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.".
- SOCS3 updateCitations "yes".
- SOCS3 updatePage "yes".
- SOCS3 updateProteinBox "yes".
- SOCS3 updateSummary "yes".
- SOCS3 type Biomolecule.
- SOCS3 type Protein.
- SOCS3 type BiologicalObject.
- SOCS3 comment "Suppressor of cytokine signaling 3 is a protein that in humans is encoded by the SOCS3 gene.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma.".
- SOCS3 label "SOCS3".
- SOCS3 sameAs m.03cv0b9.
- SOCS3 sameAs Q7392018.
- SOCS3 sameAs Q7392018.
- SOCS3 wasDerivedFrom SOCS3?oldid=593068814.
- SOCS3 isPrimaryTopicOf SOCS3.