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- SORBS2 abstract "Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene.Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.".
- SORBS2 entrezgene "8470".
- SORBS2 wikiPageID "14769775".
- SORBS2 wikiPageRevisionID "593074927".
- SORBS2 hasPhotoCollection SORBS2.
- SORBS2 requireManualInspection "no".
- SORBS2 summaryText "Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.".
- SORBS2 updateCitations "yes".
- SORBS2 updatePage "yes".
- SORBS2 updateProteinBox "yes".
- SORBS2 updateSummary "yes".
- SORBS2 type Biomolecule.
- SORBS2 type Protein.
- SORBS2 type BiologicalObject.
- SORBS2 comment "Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene.Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein.".
- SORBS2 label "SORBS2".
- SORBS2 sameAs m.03gxczx.
- SORBS2 sameAs Q7392087.
- SORBS2 sameAs Q7392087.
- SORBS2 wasDerivedFrom SORBS2?oldid=593074927.
- SORBS2 isPrimaryTopicOf SORBS2.