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- SOS1 abstract "Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]Recent studies also show that mutations in Sos1 can cause Noonan syndrome and hereditary gingival fibromatosis type 1. Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes. activators of the MAP kinase pathway.".
- SOS1 entrezgene "6654".
- SOS1 wikiPageExternalLink gene=sos1.
- SOS1 wikiPageExternalLink br.fcgi?book=gene&part=noonan.
- SOS1 wikiPageExternalLink www.noonansyndrome.org.
- SOS1 wikiPageID "9599050".
- SOS1 wikiPageRevisionID "593075199".
- SOS1 hasPhotoCollection SOS1.
- SOS1 requireManualInspection "no".
- SOS1 summaryText "RAS genes encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins . The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]".
- SOS1 updateCitations "yes".
- SOS1 updatePage "yes".
- SOS1 updateProteinBox "yes".
- SOS1 updateSummary "yes".
- SOS1 type Biomolecule.
- SOS1 type Protein.
- SOS1 type BiologicalObject.
- SOS1 comment "Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins.".
- SOS1 label "SOS1".
- SOS1 sameAs m.03bxtp0.
- SOS1 sameAs Q7392096.
- SOS1 sameAs Q7392096.
- SOS1 sameAs SOS1.
- SOS1 wasDerivedFrom SOS1?oldid=593075199.
- SOS1 isPrimaryTopicOf SOS1.