Matches in DBpedia 2014 for { <http://dbpedia.org/resource/SPAG1> ?p ?o. }
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- SPAG1 abstract "Sperm-associated antigen 1 is a protein that in humans is encoded by the SPAG1 gene.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.".
- SPAG1 entrezgene "6674".
- SPAG1 wikiPageID "14881480".
- SPAG1 wikiPageRevisionID "593079334".
- SPAG1 hasPhotoCollection SPAG1.
- SPAG1 requireManualInspection "no".
- SPAG1 summaryText "The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.".
- SPAG1 updateCitations "yes".
- SPAG1 updatePage "yes".
- SPAG1 updateProteinBox "yes".
- SPAG1 updateSummary "yes".
- SPAG1 type Biomolecule.
- SPAG1 type Protein.
- SPAG1 type BiologicalObject.
- SPAG1 comment "Sperm-associated antigen 1 is a protein that in humans is encoded by the SPAG1 gene.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens.".
- SPAG1 label "SPAG1".
- SPAG1 sameAs m.03h0881.
- SPAG1 sameAs Q7392431.
- SPAG1 sameAs Q7392431.
- SPAG1 wasDerivedFrom SPAG1?oldid=593079334.
- SPAG1 isPrimaryTopicOf SPAG1.