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- STC1 abstract "Stanniocalcin-1 is a glycoprotein, first discovered in bone fishes and latter in humans, which is encoded by the STC1 gene.This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. Human Stanniocalcin-1 is a putative molecular biomarker of leukemic microenvironment and the only molecular function known up to date is a SUMO E3 ligase activity in the SUMOylation cycle. STC1 interacts with lots of proteins in the cytoplasm, mithocondria, endoplasmatic reticulum and and dot-like fashion in the nucleus. The N-terminal region of STC1 is the function region which is responsible to establish the interaction with its partners, including SUMO1. Low resolution studies shows that STC1 is a anti-parallel homodimer in solution and the cystein 202 is responsible for the dimerization of this protein. All the 5 dissulfide bonds of human STC1 are conserved and has the same profile of fish STC. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.".
- STC1 entrezgene "6781".
- STC1 wikiPageID "14761533".
- STC1 wikiPageRevisionID "594340118".
- STC1 hasPhotoCollection STC1.
- STC1 requireManualInspection "no".
- STC1 summaryText "This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. Human Stanniocalcin-1 is a putative molecular biomarker of leukemic microenvironment and the only molecular function known up to date is a SUMO E3 ligase activity in the SUMOylation cycle. STC1 interacts with lots of proteins in the cytoplasm, mithocondria, endoplasmatic reticulum and and dot-like fashion in the nucleus. The N-terminal region of STC1 is the function region which is responsible to establish the interaction with its partners, including SUMO1. Low resolution studies shows that STC1 is a anti-parallel homodimer in solution and the cystein 202 is responsible for the dimerization of this protein. All the 5 dissulfide bonds of human STC1 are conserved and has the same profile of fish STC. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.".
- STC1 updateCitations "yes".
- STC1 updatePage "yes".
- STC1 updateProteinBox "yes".
- STC1 updateSummary "yes".
- STC1 type Biomolecule.
- STC1 type Protein.
- STC1 type BiologicalObject.
- STC1 comment "Stanniocalcin-1 is a glycoprotein, first discovered in bone fishes and latter in humans, which is encoded by the STC1 gene.This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. Human Stanniocalcin-1 is a putative molecular biomarker of leukemic microenvironment and the only molecular function known up to date is a SUMO E3 ligase activity in the SUMOylation cycle.".
- STC1 label "STC1".
- STC1 sameAs m.03gx234.
- STC1 sameAs Q7394704.
- STC1 sameAs Q7394704.
- STC1 wasDerivedFrom STC1?oldid=594340118.
- STC1 isPrimaryTopicOf STC1.