Matches in DBpedia 2014 for { <http://dbpedia.org/resource/STIM1> ?p ?o. }
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- STIM1 abstract "Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane.Even though the protein has been identified earlier, its function was unknown until recently. In 2005, it was discovered that STIM1 functions as a calcium sensor in the endoplasmic reticulum. Upon activation of the IP3 receptor, the calcium concentration in the endoplasmic reticulum decreases, which is sensed by STIM1, via its EF hand domain. STIM1 activates the "store-operated" ORAI1 calcium ion channels in the plasma membrane, via intracellular STIM1 movement, clustering under plasma membrane and protein protein interaction with ORAI isoforms. 2-Aminoethoxydiphenyl borate (2-APB) and 4-chloro-3-ethylphenol (4-CEP) cause STIM1 clustering in a cell and prevent STIM1 moving toward plasma membrane.".
- STIM1 entrezgene "6786".
- STIM1 wikiPageID "13996489".
- STIM1 wikiPageRevisionID "606332838".
- STIM1 hasPhotoCollection STIM1.
- STIM1 requireManualInspection "no".
- STIM1 updateCitations "yes".
- STIM1 updatePage "yes".
- STIM1 updateProteinBox "yes".
- STIM1 updateSummary "no".
- STIM1 type Biomolecule.
- STIM1 type Protein.
- STIM1 type BiologicalObject.
- STIM1 comment "Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane.Even though the protein has been identified earlier, its function was unknown until recently. In 2005, it was discovered that STIM1 functions as a calcium sensor in the endoplasmic reticulum.".
- STIM1 label "STIM1".
- STIM1 label "Stromal interaction molecule".
- STIM1 sameAs Stromal_interaction_molecule.
- STIM1 sameAs m.03cqhtj.
- STIM1 sameAs Q2356710.
- STIM1 sameAs Q2356710.
- STIM1 wasDerivedFrom STIM1?oldid=606332838.
- STIM1 isPrimaryTopicOf STIM1.