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- Sandra_Carson abstract "Sandra Ann Carson, M.D., is the principal innovator of the first artificial human ovary. This innovation was reported in the Journal of Assisted Reproduction and Genetics, and recognized by Time Magazine as one of the top 10 medical breakthroughs in 2010.In this work, Carson, et al. introduced theca cells donated by reproductive age patients into "3-D Petri dishes" designed to resemble the sponge-like cells of a human ovary. In the lab, the cell types interacted with one another and functioned for all intents and purposes like a real ovary, even successfully maturing a human egg from its earliest stages in the follicle to a fully developed form.To build the ovary, honeycombs of theca cells were formed, one of two key types in the ovary, donated by reproductive-age patients at Women & Infants Hospital of Rhode Island. Together with human egg cells, donated granulosa cells were inserted into the honeycomb shape the theca cells formed. In days, the theca cells enveloped the granulosa and eggs, mimicking a real ovary.Clinically, the artificial ovary could play a significant role in the future, eventually yielding new infertility treatments for women by preserving the fertility of cancer patients, for example: immature eggs could be salvaged and frozen before chemotherapy or radiation, and then matured outside the patient in the artificial ovary.In parallel with this effort and a scientific first, Carson co-directed a research team by extracting information about gene expression from fertile human egg cells without hurting them. In this work the team was able to sequence the transcribed genetic material, or mRNA, in egg cells, in smaller structures pinched off from them called polar bodies. Polar bodies are nonfunctional and incapable of being fertilized. This new technique could ultimately give parents and doctors a preview of which eggs are likely to make the most viable embryos.".
- Sandra_Carson occupation Sandra_Carson__1.
- Sandra_Carson wikiPageID "36041768".
- Sandra_Carson wikiPageRevisionID "605216597".
- Sandra_Carson education "Fellowship: Michael Reese Hospital and Medical Center".
- Sandra_Carson education "Medical School: Northwestern University Medical School".
- Sandra_Carson education "Residency: Northwestern Memorial Hospital".
- Sandra_Carson hasPhotoCollection Sandra_Carson.
- Sandra_Carson knownFor "Inventing the first artificial human ovary".
- Sandra_Carson name "Carson, Sandra".
- Sandra_Carson name "Sandra Ann Carson".
- Sandra_Carson occupation "Doctor and researcher".
- Sandra_Carson shortDescription "Medical scientist".
- Sandra_Carson description "Medical scientist".
- Sandra_Carson description "Medical scientist".
- Sandra_Carson subject Category:American_physicians.
- Sandra_Carson subject Category:Brown_University_faculty.
- Sandra_Carson subject Category:Living_people.
- Sandra_Carson subject Category:Year_of_birth_missing_(living_people).
- Sandra_Carson type Agent.
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- Sandra_Carson comment "Sandra Ann Carson, M.D., is the principal innovator of the first artificial human ovary. This innovation was reported in the Journal of Assisted Reproduction and Genetics, and recognized by Time Magazine as one of the top 10 medical breakthroughs in 2010.In this work, Carson, et al. introduced theca cells donated by reproductive age patients into "3-D Petri dishes" designed to resemble the sponge-like cells of a human ovary.".
- Sandra_Carson label "Sandra Carson".
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- Sandra_Carson givenName "Sandra".
- Sandra_Carson isPrimaryTopicOf Sandra_Carson.
- Sandra_Carson name "Carson, Sandra".
- Sandra_Carson name "Sandra Ann Carson".
- Sandra_Carson name "Sandra Carson".
- Sandra_Carson surname "Carson".